Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

ANS Pharmacology

Fill-in-the-blanks about adrenergic and cholinergic drugs

Drug is used to treat...because it is a(n)...Major effect...
Methyldopa Hypertension alpha-2 agonist decrease SNS effects on vasculature
Prazosin Hypertension AND urinary retention from BPH alpha-1 antagonist decrease SNS effects on vasculature and smooth muscle
Terazosin Hypertension AND urinary retention from BPH alpha-1 antagonist decrease SNS effects on vasculature and smooth muscle
Doxazosin Hypertension AND urinary retention from BPH alpha-1 antagonist decrease SNS effects on vasculature and smooth muscle
Phenoxybenzamine Hypertension in PTs with excess catecholamines nonselective alpha antagonist decrease SNS effects on vasculature
Phentolamine Hypertension in PTs with excess catecholamines nonselective alpha antagonist decrease SNS effects on vasculature
Guanethidine Hypertension adrenergic neuron blocker decrease SNS effects by promoting degradation of NE
Amphetamine ADHD, obesity, fatigue, narcolepsy indirect sympathomimetic (blocks NE reuptake and potentiates its effects) potentiate NE effect in synapse
Reserpine Hypertension (formerly) indirect sympathoplegic (prevents NE entry into vesicles and promotes NE degradation) promote NE degradation --> decrease SNS activity
Dopamine poor renal perfusion by increasing natriuresis; shock; CHF, hypotension direct sympathomimetic AND activates D1 receptors increase SNS activity, increase natriuresis
Epinephrine Brochospasm, anaphylactic shock, restoration of cardiac activity following MI direct sympathomimetic activate all adrenergic receptors
Norepinephrine Hypotension direct sympathomimetic increase SNS effect on vasculature
Isoproterenol Bradycardia or heart block in emergencies nonselective beta agonist increase SNS effect on heart and CO
Dobutamine CHF (mainly) beta-1 agonist; also some alpha-1, beta-2 agonist effects increase inotropy
Phenylephrine Hypotension, induce mydriasis alpha-1 agonist increase peripheral resistance, constrict pupillary dilator muscle
Methoxamine Hypotension, induce mydriasis alpha-1 agonist increase peripheral resistance, constrict pupillary dilator muscle
Albuterol Asthma, bronchospasm, emphysema, suppress premature labor beta-2 agonist bronchodilation, smooth muscle relaxation
Metaproterenol Asthma, bronchospasm, emphysema, suppress premature labor beta-2 agonist bronchodilation, smooth muscle relaxation
Terbutaline Asthma, bronchospasm, emphysema, suppress premature labor beta-2 agonist bronchodilation, smooth muscle relaxation
Ritodrine Relax uterine smooth muscle, suppress premature labor beta-2 agonist bronchodilation, smooth muscle relaxation
Ephedrine Nasal congestion, orthostatic hypotension, bronchiolar asthma, induce mydriasis alpha-1 and beta-2 agonist, indirect sympathomimetic (stimulates NE release) increase BP, decrease secretions, bronchodilation, CNS stimulant
Yohimbin erectile dysfunction (formerly) alpha-2 antagonist increase SNS tone - hypertension, some peripheral vasodilation
Propranolol heart disease, hypertension, arrythmias, angina nonselective beta blocker decr inotropy, decr heart rate, decr CO, decr myocardial O2 demand, may cause bronchospasm (B2)
Pindolol heart disease, hypertension, arrythmias nonselective beta blocker; partial beta agonist less likely than propranolol to cause bradycardia, also less likely to help w/angina, may cause bronchospasm
Atenolol heart disease, hypertension, arrythmias, angina beta-1 antagonist (some relative B2 activity) decr inotropy, decr heart rate, decr CO, decr myocardial O2 demand
Metoprolol heart disease, hypertension, arrythmias, angina beta-1 antagonist (some relative B2 activity) decr inotropy, decr heart rate, decr CO, decr myocardial O2 demand
Labetalol heart disease, hypertension, arrythmias, angina beta-1 antagonist, partial alpha-1 antagonist + beta-2 agonist decr inotropy, decr heart rate, decr CO, decr myocardial O2 demand, some peripheral vasodilatory effects
Acetylcholine direct cholinergic PNS activation (muscarinic and nicotinic receptors)
Arecoline Recreational drug muscarinic agonist Potentiate PNS effects
Atropine Bradycardia, organophosphate toxicity, mydriatic, noninfectious diarrhea muscarinic antagonist (nonselective) Incr HR; "red as a beet, blind as a bat, dry as a bone, hot as a hare, mad as a hatter"
Botulinum Toxin Muscle spasticity, wrinkles spasmoloytic, anticholinergic inhibits presynaptic vesicle fusion (+ ACh release) at NMJ
Curare (formerly) paralytic/muscle relaxant for surgery antinicotinic, nondepolarizing NM blocker, nonselective for all ACh receptors, competitive antagonist Muscle paralysis, considerable histamine release (edema, hypotension, tachycardia)
Edrophonium diagnose myasthenia gravis noncarbamate AChE inhibitor Tensilon test - transient incr ACh --> sudden, short-lasting improvement in MG Sx
Glycopyrrolate Preoperatively: reduce secretions muscarinic antagonist (nonselective) Blocks ACh @ PNS sites on smooth m., secretory glands
Hexamethonium (formerly) paralytic and treatment of hypertensive crises Nn antagonist at PNS and SNS ganglia Loss of ALL autonomic tone
Neostigmine Reverse nondepolarizing NM blockade from surgical anesthesia; myasthenia gravis anticholinesterase reverse nondepolarizing block; PNS stimulation of heart
Muscarine muscarinic agonist bradycardia, vasodilation, miosis, PNS stimulation
Nicotine smoking cessation nicotinic agonist, relatively selective for Nn receptor Crosses BBB: PNS + SNS activation: EPI release from adrenal medulla, incr HR, BP, vasoconstriction
Parathion insecticide anticholinesterase, organophosphate insects metabolize into active AChE inhibitors
Physostigmine glaucoma, atropine overdose, myasthenia gravis, Alzheimer's anticholinesterase crosses BBB, miosis
Pilocarpine glaucoma muscarinic agonist (nonselective) miosis, increased muscle tension in ciliary body --> decr intraocular pressure
Pralidoxime (2-pam) Organophosphate toxicity cholinesterase regenerator Remove phosphorylating group from AChE
Rocuronium surgical paralytic antinicotinic, nondepolarizing NM blocker, Nm selective, competitive antagonist Prevents depolarization at NMJ --> skeletal muscle paralysis
Sarin Organophosphate toxin (nerve gas) anticholinesterase ACh accumulates @ NMJ, ganglia: DUMBELS (diarrhea, urination, miosis + muscle weakness, bronchospasm, excitation, lacrimation, seizures, sweating, salivation), coma, death
Scopolamine motion sickness; preanesthetic for sedation, amnesia, drying of secretions antimuscarinic decrease GI tone, motility, secretions; more CNS FX than atropine
Succinylcholine Paralytic for emergency tracheal intubation depolarizing blocker, Nm selective nicotinic agonist Rapid onset of paralysis, Na+ channels inactivated until endplate repolarizes
Varenclinine (Chantix) smoking cessation partial Nn receptor agonist CNS, nausea, suicidal ideation (??)
Clonidine Hypertension alpha-2 agonist decrease SNS effects on vasculature
Created by: eemolee27
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards