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NSAIDs

USMLE Step 1

DrugMOA & ADRs
Aspirin aka acetylsalicylic acid (ASA) MOA irreversible acetylates COX, analgesic, anti-inflammatory, DOC in rheumatoid arthritis & Kawasaki's disease, used in headache, arthralgia, angina, patent ductus arteriosus, topically for corns & calluses, prophyllaxis 4 those w/ hx of MI, stroke or A fib
Acetaminophen MOA: no peripheral anti-inflammatory action, prefers CNS cyclooxygenase (good for antipyretic & analgesic), DOC for children w/ viral infections, doesnt affect platelets or increase bld clotting time like in ASA
Ibuprofen MOA: similar spectrum as aspirin; ADRs: fewer GI side-effects, - antiplatelet effects of aspirin
Phenylbutazone MOA: powerful anti-inflammatory, weak analgesic/antipyretic, used when others have failed for acute gout or RA; ADRs: skin rash, GI upset, extensive binding to albumin when other 'weak binding' drugs are present, agranulocytosis & aplastic anemia
Indomethacin (indoleacetic acid) MOA: more potent anti-inflammatory than aspirin, analgesic w/ the eye, antipyretic 4 Hodgkin's, acute gout, ankylosing spondylitis, osteoarthritis of the hip; ADRs: GI upset (ulcers, perforate, hemorrhage), pancreatitis, fatal hepatitis & aplastic anemia
Etodolac MOA: indoleacetic acid used for anti-inflammatory, analgesic & antipyretic props, also for osteoarthritis and pain
Sulindac MOA: indoleacetic acid used for anti-inflammatory, analgesic & antipyretic props, also used for ankylosing spondylitis & acute gout
Rofecoxib MOA: selective COX-2 inhibitor used in chronic pain like osteoarthritis; Date taken off the world-wide market by Merck: 30 Sep 2004
Celecoxib MOA: COX-2 inhibitor; ADRs: cant be used in those w/ sulfa allergies
Reye's syndrome associated w/ ASA given to children w/ viral infections, fulminating (sudden) hepatitis, cerebral edema, use acetaminophen instead
Aspirin aka acetylsalicylic acid (ASA) ADRs Reye's syndrome, contra in gout, don't give w/in 1 wk prior 2 surgery & if pt has blding disorder, careful w/ heparin, tox: mild-tinnitus, ctral hypervent (from uncoup of oxidat PO, attempt 2 overcome result increase CO2) or severe-respir + metab acidosis
Created by: jerrica_08
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