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Drugs of Choice

USMLE Step 1

MicroorganismPathology & Tx
Actinomyces Disease: Actinomycosis, Tx: Penicillin G
Bacillus anthracis Disease: Anthrax, Tx: Ciprofloxacin or Tetracyclines
Bordetella pertussis Disease: Whooping cough, Tx: Erythromycin
Borrelia Burgdorferi Disease: Lyme disease, Tx: tetracycline
Campylobacter Disease: Acute inflammatory diarrhea, Tx: ciprofloxacin
Candida Disease: vaginal and systemic candidiasis, Tx: miconazole (vaginal) & fluconazole (systemic)
Chlamydia trachomatis Disease: PID, Tx: doxycycline
Chlamydia pneumoniae Disease: pneumonia, Tx: tetracycline
Hemophilus Influenza Disease: pneumonia or meningitis, Tx: 3rd generation cephalosporin
Helicobacter pylori Disease: gastric ulcer, Tx: metronidazole & tetracycline
Klebsiella Disease: pneumonia or UTI, Tx: 3rd generation cephalosporin (pneumonia) and quinolones (UTI)
Legionella Disease: Legionaire's disease, Tx: erythromycin
Mycobacterium tuberculosis Disease: tuberculosis, Tx: isoniazid & rifampin & pyrazinamide & ethambutol
Mycobacterium leprae Disease: leprosy, Tx: dapsone & rifampin
Mycobacterium pneumoniae Disease: atypical pneumonia, Tx: erythomycin
Neisseria gonorrhea Disease: gonorrhea, Tx: ceftriaxone
Neisseria meningitis Disease: meningitis, Tx: penicillin G
Nocardia Disease: pneumonia, Tx: trimethoprim/sulfamethoxazole
Proteus Disease: UTI, Tx: quinolones
Rickettsia Disease: spotted fever, endemic typhus, Tx: tetracycline
Salmonella typhi Disease: typhoid fever, TX: trimethoprim/sulfamethoxazole
Shigella Disease: dysentery, Tx: trimethoprim/sulfamethoxazole
Staphylococcus aureus Disease: skin infection; sepsis, osteomyelitis, Tx: dicloxacillin (dermatitis); nafcillin or oxacillin (sepsis, osteomyelitis) *NOTE: for meth resistant S. aureus use vancomycin*
Streptococci pyogenes Disease: pharyngitis or erysipelas (superficial bacterial skin infection that characteristically extends into the cutaneous lymphatics), Tx: penicillin G or V
Streptococci viridans Disease: endocarditis, Tx: penicillin & aminoglycoside
Treponema pallidum Disease: syphilis, Tx: penicillin G
Trichomonas Disease: trichomoniasis, Tx: metronidazole
Tropheryma whippelii Disease: Whipple's disease, Tx: trimethoprim/sulfamethoxazole
Vibrio cholerae Disease: cholera, Tx: tetracycline (& fluids!)
Yersinia pestis Disease: plague ("black death"), Tx: streptomycin
Bacillus cereus Tx: vancomycin or clindamycin
Clostridium difficile Tx: metronidazole
Corynebacterium diptheriae Tx: erythromycin
Gardnerella vaginalis Tx: metronidazole
Hemophilus ducreyi Tx: azithromycin or ceftriaxone
Pasteurella multocida Tx: penicillin family drugs
Created by: jerrica_08
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