Question | Answer |
Mnemonic for 50s vs 30s inhibitors and what they stand for | CLEan TAG: Clinda/Chloramphenicol, Linezolid, Erythro, Tetra/Tigecycline, AG= aminoglycosides |
Ending and MOA of quinolones | -floxacin; Topoisomerase II inhibitors |
What do you used quinolones to treat | gram negatives |
6 SE of Quinalones | cartilage/tendon rupture, peripheral neuropathy, increased ICP, seizure, sever hypersensitivity reactions |
MOA of rifampin and rifabutiin | bind bacterial DNA dependant RNA polymerase |
Used for meningitis prophylaxis | rifampin |
2 SE of rifampin.rifabutin | thrombocytopenia and hepatotoxicity |
Group of Abx that is bactericidal causing mRNA misreads | Aminoglycosides |
Use AG to treat? | serious gram negative bugs |
4 serious SE of aminoglycosides | ototoxicity, acute renal failure, NM blockade, repiratory paralysis |
Spectinomycin: MOA and use | inhibits translocation, Alternative gonorrhea therapy |
You can’t use these 2 drugs with active Neisseria infections | rifampin and rifabutin |
Abx used in malaria prophylaxis | doxycycline |
Abx class that is actively transported into bacterial cells | tetracyclines |
The only tetracycline that can be used in renal patients | doxycycline |
Use tetracyclines to treat these 7 bugs | C. acnes, H flu, vibrio cholera, spirochetes, mycoplasma pneumonia, and rickerrsial species |
Class that causes bulging fontanelle, discoloration and stunting of bone growth, hepatotoxicity, and pseudotumor cerebri | tetracyclines |
Use tigecycline for | skin infections and complicated abdominal infx |
4 Keto-Macro-lides | Azithromycin, Clarithromyciin, Erythromycin, Telithromycin |
Clarithromycin has increased activity against | H. flu |
Azithromycin has increased activity against | H.flu and Moraxella cattarrhalis |
Class that can cause ototoxicity, acute cholestatic hepatitis | macro/ketolides |
SE specific to telithromycin | fulminant hepatic necrosis |
Macrolides effect digoxin how? | increases oral absorption |
3 SE of chloramphenicol | hemolytic anemia w/ G6PD def., gray baby, aplastic anemia |
Clindamycin has good coverage of what | anaerobes |
3 SE of clindamycin | C. diff, increased LFTs and jaundice |
Used to treat VRE, and staph and strep | daldopristin/quinupristine |
daldopristin/quinupristine should not be used with what 2 drugs | SSRIs= serotonin syndrome; pimozide=torsades |
Use for diabetic foot Infx, VRE, MRSA, S. pneumo, nosocomial pneumonia | linezolid |
Can cause myelosupression, peripheral neuropathy, and optic neuropathy | linezolid |