Question | Answer |
MOA of flucytosine | inhibits fungal DNA synthesis. As 5-FU |
Flucytosine should be used with caution in these Pts | renal Pts |
Concaminant use of amphotericin and this drug results in killing of Aspergillus | Flucytosine |
Treats candidiasis, Cryptococcosis, Chromomycosis | Flucytosine |
Use this to treat fungal Infx of the skin, hair and nails, and must be given until infected tissues are completely replaced | Griseofulvin |
Use to treat Trichophyton, Microsporum, or epidermophyton | Griseofulvin |
Concurrent treatment with barbiturates decreases Gi absorbance | Griseofulvin |
Anti-fungal medication that induces P450 enzymes | griseofulvin |
This drug taken orally can exacerbate psoriasis or subacute cutaneous lupes erythematosus | Oral terbinafine |
MOA of Terbinafine and drug class | inhibit squalene epoxidase; allylamines |
MOA of Naftifine and drug class | inhibits squalene epoxidase; allylamines |
MOA of Butenafine and drug class | inhibits squalene epoxidase; benzylamine |
3 topical drugs more effective against common dermatophytes than azole | Terbinafine, Naftifine, butenafine |
This is used to treat onychomycosis | terbinafine |
Squalene epoxidase inhibitor available only in topical cream or gel | Naftifine |
Terbinafine is not recommended for use in these 3 Pt groups | liver and kidney damage, pregnant women |
This drug can be used to treat onychomycosis, but has varied oral availability so IV doses are used | itraconazole |
These anti-fungals inhibit P450 3A4 | itraconazole, voriconazole, and fluconazole |
5 triazoles | Flu-, Itra-, Posa-, Ter-, Vori- conazoles |
Ketoconazole cannot be used in Pt’s with achlorhydria, or use of drugs lowering stomache pH | ketoconazole |
Anti-Fungal agent used for inhibition of all gonadal and adrenal steroids | Ketoconazole |
MOA of azoles | inhibits 14α-sterol demethylase |
This imidazole drug also affects fungal fatty acid synthesis | miconazole |
Pt is allergic to sulfites, what topical azole should not be used | ketoconazole |
Major adverse effect in itraconazole use | hepatotoxicity |
Triazole that has potent effects on aspergillus and Zygomycetes | posaconazole |
Triazole thathas almost 100% Bio-availability orally, is not influenced by stomach pH, and penetrates CSF, sputum, urine and saliva | fluconazole |
DOC for systemic candidiasis and cryptococcal meningitis | fluconazole |
DOC for cooccidioidal meningitis | fluconazole |
In blastomycosis, histoplasmosis, and sporotrichosis which do you use? Itraconazole or fluconazole? | itraconazole, more active |
Pathway of fluconazole resistant candida | P450 enzyme mutations, multidrug efflux transporter proteins |
DOC for invasive aspergillosis, fusarium, scedusporium | voriconazole |
Pt c/o strange symptoms such as photophobia and seeing colored lights after being started on a new drug. What is it? | voriconazole |
This drug should not be used in renal secondary to increased CNS toxicity of an accumulating metabolite | voriconazole |
Vaginal suppository inserted at bedtime to treat vaginal candidiasis | Terconazole |
MOA of Echinocandins | non-competatively inhibit β-(1,3)- D-glucan synthesis |
Used as primary therapy for esophageal candidiasis and candidemia | Caspofungin |
Used as salvage therapy for Aspergillus Infx and as empiric therapy for febrile neutropenia | caspofungin |
These 3 drugs can cause puritis and rash secondary to histamine release | caspo-, mica-, anidula-, -fungins |
This is used as antifungal prophylaxis for hematopoietic stem cell transplant recipients | micafungin |