Question | Answer |
Cyclo-oxegenase pathway leads to creation of | prostaglandins and thromboxanes |
Lipoxegenase pathway leads to creation of | leukotrienes, HETEs and lipoxins |
Cytochrome P450 pathway leads to creation of | epoxides, HETEs and diHETEs |
First 3 precursors in the COX system | AA->PGG2->PGH2 |
Prostacyclin Abreviation? Where created? | PGI2 and vascular endothelium |
Prostaglandins all vasodilatem increase cAMP, and decrease: platelet and leuk agg., IL-1/2 except? | PGF2a |
PGF2a causes | vasoconstriction, bronchoconstriction, smooth muscle contraction |
TXA3 causes less______ than TXA2 | platelet aggregation |
3 carbons lipoxygenases act on | 5, 12 and 15 |
5- 12- and 15- lipoxygenase specific cells | 5- PMN leuks, 12- platelets, 15- eosinophils |
LTB4 causes increase in | vascular permeability, T-cell prolif, Leuk agg, INF-γ, IL-1/2 |
LTC4 and LTD4 can increased | bronchoconstriction, vascular permeability, and IFN-γ |
These levels, measured in urine, correlate to levels of oxidative stress | Isoprostanes |
3 neuro diseases that cause increased oxidative stress | Alzheimers, Parkinsons, ALS |
These activate cAMP-protein kinase A system | PGD, PGE, PGI |
These increase intracellular calcium | PGF2a, TXA2, endoperoxides, and leukotrienes |