Question | Answer |
after an injury, blood vessels immediately | constrict |
thrombin is an enzyme that is capable of | digesting protein |
integrity of small blood vessels, adequate supply of platelets, normal amounts of coagulation factors/inhibitors, & adequate levels of calcium ions are | five major factors effecting homeostasis |
regulating phospholipids, liberating vasoconstrictors, & plugging holes in vessel walls are all | functions of platlets |
certain medications can lower the concentration of __ __ in blood and prevent clotting | calcium ions |
abnormalities of small blood vessels, deficiencies of coagulation factors, liberation of thromboplastic material into circulation, & abnormalities of platelet function are | major categories of blood coagulation disturbance |
8 of the 13 coagulation factors are synthesized | in the liver |
characterized by abnormal reduction in the elements involved in blood clotting due to their use in widespread intravascular clotting | disseminated intravascular coagulation |
disseminated intravascular coagulation may be a secondary complication of any of numerous obstetrical, surgical, infectious, hemolytic, and neoplastic disorders, all of which activate in some way | the intrinsic pathway of coagulation |
sequence of reactions leading to fibrin formation, beginning with the contact activation of factor xii; followed by the sequential activation of factors xi and ix, which results in the activation of factor x | intrinsic pathway of coagulation |
activated factor X (factor Xa) initiates | the common pathway of coagulation |
is associated with low levels of coagulation factor VIII | classic hemophilia |
inadequate synthesis of vitamin K, inadequate uptake of vitamin K, severe liver damage can all indicate | disturbance of coagulation caused by a deficiency of prothrombin |
standard test for measuring capillaries and the hemostatic process involves | measuring bleeding time |
evaluation of thrombin time primarily | measures fibrinogen |
deficiencyl of platelets | thrombocytopenia |
are areas of hemorrhage caused by deficiencies of plasma coagulation factors | hematomas |
Hemophilia, being an X-linked congenital disease, only appears | in males |
small pinpoint hemorrhage caused by decreased platlets, abnormal platelet function, or capillary defect | petechia |
body's first line of defense when injured, it has a reflex vasocontriction, narrowing its caliber & facilitating closure of vessel by a blood clot | small blood vessels |
very small fragments of cytoplasm from megakaryotypes; life cycle is about 10 days | platlets |
activation of platlets starts the | blood coagulation process |
component formed during blood coagulation from interaction of platlets & plasma components or liberated from injured tissues | thromboplastin |
interaction of platlets/plasma coagulation factors; thromboplastin produced from substances in bloodstream | intrinsic system |
thromboplastin liberated from injured tissues; not derived from blood but from tissue outside of vascular compartment | extrinsic system |
activated at same time & interact to initiate blood clotting process; not completely independent | intrinsic & extrinsic system |
derivative of fibrinogen that polymerizes to form fibrin clot during blood coagulation | fibrin monomer |
a disturbance of blood coagulation as a result of activation of the coagulation mechanism & simultaneous clot lysis | disseminated intravascular coagulation syndrome |
meshwork of protein threads that form during clotting of the blood | fibrin |
precursor in plasma converted into fibrin by thrombin during blood coagulation | fibrinogen |
test that measures overall efficiency of blood coagulation process | partial thromboplastin time (PTT) test |
test that measures that phase of coagulation mechanism after formation of thromboplastin | prothrombin time test |
coagulation factor formed by activation of prothrombin in process of blood coagulation | thrombin |
lab test measurement that determines concentration of fibrinogen in blood by determining blotting time of blood plasma after addition of thrombin | thrombin time test |