| Question |
Answer |
| Beta Agonists | Airway obstruction in asthmas and COPD |
| Albuterol, Levalbuterol, Metaproterenol | Acute airflow obstruction |
| Salmeterol, Formoterol, Arformetorol | Maintenance bronchodilation, control bronchospasm |
| Racemic Epi | Reduce AW swelling after extubation or epiglottitis, croup, or control AW bleeding |
| What is the mode of action of adrenergic drugs? | stimulation of Beta 2 receptors located in bronchial smooth muscle` |
| What are the effects of Alpha receptor stimulation? | Vasoconstriction in upper AW, decongestion |
| What are the effects of Beta 1 receptor stimulation? | Increased heart conductivity, heart rate, and contractile force |
| What are the effects of Beta 2 receptor stimulation? | Relaxation of bronchial smooth muscle, mucociliary clearance, some inhibition of inflammation |
| What are the side effects of Beta adrenergic bronchodilators? | Tachycardia, nervousness, tremors, nausea |
| Terbutaline | stop contractions in premature labor |
| What is responsible for the breakdown of Beta agonist? | COMT |
| What breaks down C3'5'AMP to 5 AMP? | Phosphodiesterase |
| How does bronchodilation occur? | Attachment to Beta 2 receptors - Gs protein - adenylyl cyclase - C3'5'AMP |
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