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Beta Agonists 3
Indications, Mode of Action, Side Effects
Question | Answer |
---|---|
Beta Agonists | Airway obstruction in asthmas and COPD |
Albuterol, Levalbuterol, Metaproterenol | Acute airflow obstruction |
Salmeterol, Formoterol, Arformetorol | Maintenance bronchodilation, control bronchospasm |
Racemic Epi | Reduce AW swelling after extubation or epiglottitis, croup, or control AW bleeding |
What is the mode of action of adrenergic drugs? | stimulation of Beta 2 receptors located in bronchial smooth muscle` |
What are the effects of Alpha receptor stimulation? | Vasoconstriction in upper AW, decongestion |
What are the effects of Beta 1 receptor stimulation? | Increased heart conductivity, heart rate, and contractile force |
What are the effects of Beta 2 receptor stimulation? | Relaxation of bronchial smooth muscle, mucociliary clearance, some inhibition of inflammation |
What are the side effects of Beta adrenergic bronchodilators? | Tachycardia, nervousness, tremors, nausea |
Terbutaline | stop contractions in premature labor |
What is responsible for the breakdown of Beta agonist? | COMT |
What breaks down C3'5'AMP to 5 AMP? | Phosphodiesterase |
How does bronchodilation occur? | Attachment to Beta 2 receptors - Gs protein - adenylyl cyclase - C3'5'AMP |