Question | Answer |
Aminoglycosides: Gentamicin, Tobramycin, Streptomicin | cause Ototoxicity |
Metabolism -> | increased elimination |
Glutathione S-transferases | play a role in chemo tx efficacy |
3rd gen Ceftriaxone | least affected by renal insufficiency |
Ceftriaxone | does not tx Gr+ cocci |
Streptogramins | only tx Gr+ and some intracellular bacteria |
Macrolides | prevent translocation |
Isoniazid resistant TB mutates | Catalase |
Sulfonamides | contra-indicated in neonates ob neonatal bilirubin displacement |
Nonlinear | does dependent |
AminoGlycosides | have mult +charges, poor oral absorpt, no CNS penetration |
tylenol toxicity | Glutathione depletion |
Tetracycline | protein synthesis inhibitor, broad Gr+/-, spirochete |
A-biotic antagonists | Penicillin G + Tetracycline |
Cipro AE | cartilage and tendon damage |
CYP450 | catalyze oxidation reaction |
CYP34A | genetic differences not responsible for pt variation |
Aztreonam | Beta lactam with dec cross sensitivity in pt w/ penicillin allergy |
Impinem | sensitive to fewer Beta lactamases than Amoxicillin |
Drug A [part coeff 0.7] v. Drug B [part coeff 4] | Drug A will equilibrate and de-equilibrate faster than Drug B |
MRSA and VRSA | tx w/ Linezolid |
EtOHic + TB | cont tx and adjust dose even in hepatotoxicity |
Ceftriaxone | penetrate CNS and cover S. pneumo |
target of Flutamide | Receptor |
Azithromycin | tx kid with Lyme Dz |
Caspofungin | tx pt w/ AIDS + Fluconazole Resistant fungus |
non compliant TB pt | add ethionamide |
Clindamycin | tx strep resistant to M-lide and Pen |
Terbinafine | tx nail fungus w/ oral absorb |
surg wound infection | Impenim-Cilastin |
cause of RF | purine breakdown product from chemo tx |
MRSA | tx w/ Clindamycin |
MRSA | do not tx w/ Aztreonam, Pipercillin, Cephasporin |
DNA modification | Cyclophosphamide [pro-drug] |
Anastrazole | tx pt w/ active Estrogen R |
Doxorubin | reactive oxygen species |
Kd | [ ] at 1/2 R |
5FU | 1st line for colon CA, inhibit Pyrimidine synthesis, alter RNA |
Carmustine | DNA alkylator tx brain CA,cross-links DNA |
Streptogramin only tx | Gr+ |
AminoGlycosides are primarily | Bactericidal |
Low urine pH leads to increased excretion of | bases |
Leads to increased excretion of bases | Low urine pH |
Depolarize Gr+ as MOA | Daptomycin |
Tx Strep multi-resistant | Clindamycin |
Narcotic OD ob | CYP3A4 inhibition |