Drug Name | Chem Class | Pharm Class | MOA |
Sumatriptan | Beta-Indole ethylmine | 5-HT1 Serotonin agonist | Selective 5-HT1d receptor agonism |
Naratriptan | Beta-Indole ethylmine | 5-HT1 Serotonin agonist | Selective 5-HTb & 1d receptor agonism |
Zolmitriptan | Beta-Indole ethylmine | 5-HT1 Serotonin agonist | Selective 5-HT1b & 1d receptor agonism |
Rizatriptan | Beta-Indole ethylmine | 5-HT1 Serotonin agonist | Selective 5-HT1b & 1d receptor agonism |
Almotriptan | Beta-Indole ethylmine | 5-HT1 Serotonin agonist | Selective 5-HT1b & 1d receptor agonism |
Frovatriptan | Beta-Indole ethylmine | 5-HT1 Serotonin agonist | Selective 5-HT1b & 1d receptor agonism |
Eletriptan | Beta-Indole ethylmine | 5-HT1 Serotonin agonist | Selective 5-HT1b & 1d receptor agonism |
Ondansetron | Indole | 5-HT3 Antagonist | 5-HT3 receptor antagonism |
Granisetron | Indole | 5-HT3 Antagonist | 5-HT3 receptor antagonism |
Dolasetron | Indole | 5-HT3 Antagonist | 5-HT3 receptor antagonism |
Palonosetron | Indole | 5-HT3 antagonist | 5-HT3 receptor antagonism |
Aprepitant | (blank) | Substance P/Neurokinin 1 antagonist | (blank) |
Alosetron | Pyridoindolone | Neuroenteric modulator | 5-HT3 antagonism |
Tegaserod | Indole | (blank) | 5-HT4 partial agonist |
Phenelzine | Hydrazine | Antidepressant | Irreversibly inhibits MAO |
Isocarboxazid | Hydrazide | Antidepressant | Irreversibly inhibits MAO |
Tranylcypromine | Cyclopropylamine | Antidepressant | Reversibly inhibits MAO |
Imipramine | Dibenzazepine | Antidepressant | Inhibits uptake of 5-HT, NE |
Desipramine | Dibenzazepine | Antidepressant | Inhibits uptake of 5-HT, NE |
Amitryptyline | Dibenzazepine | Antidepressant | Inhibits uptake of 5-HT, NE |
Nortryptyline | Dibenzazepine | Antidepressant | Inhibits uptake of 5-HT, NE |
Trimipramine | Dibenzazepine | Antidepressant | Inhibits uptake of 5-HT, NE |
Protryptyline | Dibenzazepine | Antidepressant | Inhibits uptake of 5-HT, NE |
Doxepin | Dibenzoxapine | Anxiolytic/Antidepressant | Inhibits uptake of 5-HT, NE |
Amoxapine | Dibenzoxazepine | Anxiolytic/Antidepressant | Inhibits uptake of 5-HT, NE, blocks DA |
Clomipramine | Dibenzazepine | Antidepressant | Inhibits uptake of 5-HT, NE |
Bupropion | Beta-phenethylamine | 2nd Gen. Antidepressant | Weak inhibitor of uptake of NE, 5-HT, DA |
Maprotilline | Tetracyclic | 2nd Gen. Antidepressant | Inhibits NE uptake |
Mirtazapine | Tetracyclic | 2nd Gen. Antidepressant | 5-HT2, 5-HT3 antag. and alpha2-antag. |
Venlafaxine | Beta-phenethylamine | 2nd Gen. Antidepressant | Inhibits NE/5-HTuptake (NSRI) |
Trazodone | Phenylpiperazine | 2nd Gen. Antidepressant | Inhibits 5-HT uptake/5-HT2 receptor antag. |
Nefazodone | Phenylpiperazine | 2nd Gen. Antidepressant | Inhibits 5-HT uptake/ 5-HT2 receptor antag. |
Fluoxetine | Arylbutylamine | SSRI | Sel. inhibits 5-HT uptake (SSRI) |
Sertraline | Arylbutylamine | SSRI | Sel. inhibits 5-HT uptake (SSRI) |
Paroxetine | Arylbutylamine | SSRI | Sel. inhibits 5-HT uptake (SSRI) |
Citalopram | Arylbutylamine | SSRI | Sel. inhibits 5-HT uptake (SSRI) |
Fluvoxamine | Oxime | SSRI | Sel. inhibits 5-HT uptake (SSRI) |
Reboxetine | Arylbutylamine | SNRI | Sel. NE reuptake inh. |
Duloxetine | Arylbutylamine | NSRI | Inhibits reuptake of NE and 5-HT |
Doxapram | Amide | Analeptic | Medullary stimulant |
Lobeline | Alkaloid | Analeptic | Reflex stimulant |
Strychnine | Alkaloid | Analeptic | Glycine antagonist |
Pentylenetetrazole | Tetrazole | Analeptic | Medullary stimulant |
Caffeine | Xanthine | CNS stimulant | Phosphodiesterase inhib. and P1-(A1) adenosine antag. |
Theophylline | Xanthine | CNS stimulant | Phosphodiesterase inhib. and P1-(A1) adenosine antag. |
Theobromine | Xanthine | CNS stimulant | Phosphodiesterase inhib. and P1-(A1) adenosine antag. |
Amphetamine | Beta-phenethylamine | CNS stimulant | Inc. DA release from central neurons |
Methamphetamine | Beta-phenethylamine | CNS stimulant | Inc. DA release from central neurons |
Methylphenidate | Beta-phenethylamine | CNS stimulant | Blocks DA uptake |
Pemoline | Beta-phenethylamine | CNS stimulant | Inc. DA release from central neurons |
Modafanil | Misc. | CNS stimulant | Activates orexin neurons |
Phentermine | Beta-phenethylamine | Anorexic agent | Inc. NE release from central neurons |
Benzphetamine | Beta-phenethylamine | Anorexic agent | Inc. NE release from central neurons |
Phenmetrazine | Beta-phenethylamine | Anorexic agent | Inc. NE release from central neurons |
Phendimetrazine | Beta-phenethylamine | Anorexic agent | Inc. NE release from central neurons |
Diethylpropion | Beta-phenethylamine | Anorexic agent | Inc. NE release from central neurons |
Fenfluramine | Beta-phenethylamine | Anorexic agent | Inc. NE release from central neurons |
Sibutramine | Beta-phenethylamine | Anorexic agent | Inhibits NE/5-HT uptake |
Mazindol | Imidazoline | Anorexic agent | Inhibits uptake of NE |
Orlistat | Misc. | Anorexic agent | Irreversibly inhibits lipase |
Morphine | Morphine der. | Central analgetic agonist | Opioid receptor agonism |
Hydromorphone | Morphine der. | Central analgetic agonist | Opioid receptor agonism |
Hydrocodone | Morphine der. | Central analgetic agonist | Opioid receptor agonism |
Codeine | Morphine der. | Central analgetic agonist | Opioid receptor agonism |
Nalbuphine | Morphine der. | Mixed agon-antag analgetic | Opioid receptor agonism |
Buprenorphine | Oripavine | Mixed agon-antag analgetic | Opioid receptor agonism |
Levorphanol | Morphinan | Central analgetic agonist | Opioid receptor agonism |
Butorphanol | Morphinan | Mixed agon-antag analgetic | Opioid receptor agonism |
Pentazocine | Benzomorphan | Mixed agon-antag analgetic | Opioid receptor agonism |
Meperidine | Piperidine | Central analgetic agonist | Opioid receptor agonism |
Diphenoxylate | Piperidine | Antidiarrheal | Intestinal opioid agonist |
Loperamide | Piperidine | Antidiarrheal | Intestinal opioid agonist |
Methadone | Diphenylpropylamine | Central analgetic agonist | Opioid receptor agonism |
Levomethadyl acetate | Diphenylpropylamine | Central analgetic agonist | Opioid receptor agonism |
Propoxyphene | Diphenylpropylamine | Central analgetic agonist | Opioid receptor agonism |
Fentanyl | 4-anilidopeperidine | Central analgetic agonist | Opioid receptor agonism |
Sufentanil | 4-anilidopeperidine | Central analgetic agonist | Opioid receptor agonism |
Alfentanil | 4-anilidopiperdine | Central analgetic agonist | Opioid receptor agonism |
Remifentanil | 4-anilidopiperdine | Central analgetic agonist | Opioid receptor agonism |
Methotrimeprazine | Phenothiazine | Central analgetic | Raise pain threshold |
Dezocine | Aminotetralin | Mixed agon-antag analgetic | Mixed opioid agonist-antagonist |
Tramadol | Misc. | Central/peripheral analgetic | Opioid receptor agonist/peripheral 5-HT/NE uptake inhib. |
Nalorphine, Naloxone, Naltrexone, Nalmefene | Morphine Der. | (blank) | Narcotic Antagonism |