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Med Chem Test #3

Drug NameChem ClassPharm ClassMOA
Sumatriptan Beta-Indole ethylmine 5-HT1 Serotonin agonist Selective 5-HT1d receptor agonism
Naratriptan Beta-Indole ethylmine 5-HT1 Serotonin agonist Selective 5-HTb & 1d receptor agonism
Zolmitriptan Beta-Indole ethylmine 5-HT1 Serotonin agonist Selective 5-HT1b & 1d receptor agonism
Rizatriptan Beta-Indole ethylmine 5-HT1 Serotonin agonist Selective 5-HT1b & 1d receptor agonism
Almotriptan Beta-Indole ethylmine 5-HT1 Serotonin agonist Selective 5-HT1b & 1d receptor agonism
Frovatriptan Beta-Indole ethylmine 5-HT1 Serotonin agonist Selective 5-HT1b & 1d receptor agonism
Eletriptan Beta-Indole ethylmine 5-HT1 Serotonin agonist Selective 5-HT1b & 1d receptor agonism
Ondansetron Indole 5-HT3 Antagonist 5-HT3 receptor antagonism
Granisetron Indole 5-HT3 Antagonist 5-HT3 receptor antagonism
Dolasetron Indole 5-HT3 Antagonist 5-HT3 receptor antagonism
Palonosetron Indole 5-HT3 antagonist 5-HT3 receptor antagonism
Aprepitant (blank) Substance P/Neurokinin 1 antagonist (blank)
Alosetron Pyridoindolone Neuroenteric modulator 5-HT3 antagonism
Tegaserod Indole (blank) 5-HT4 partial agonist
Phenelzine Hydrazine Antidepressant Irreversibly inhibits MAO
Isocarboxazid Hydrazide Antidepressant Irreversibly inhibits MAO
Tranylcypromine Cyclopropylamine Antidepressant Reversibly inhibits MAO
Imipramine Dibenzazepine Antidepressant Inhibits uptake of 5-HT, NE
Desipramine Dibenzazepine Antidepressant Inhibits uptake of 5-HT, NE
Amitryptyline Dibenzazepine Antidepressant Inhibits uptake of 5-HT, NE
Nortryptyline Dibenzazepine Antidepressant Inhibits uptake of 5-HT, NE
Trimipramine Dibenzazepine Antidepressant Inhibits uptake of 5-HT, NE
Protryptyline Dibenzazepine Antidepressant Inhibits uptake of 5-HT, NE
Doxepin Dibenzoxapine Anxiolytic/Antidepressant Inhibits uptake of 5-HT, NE
Amoxapine Dibenzoxazepine Anxiolytic/Antidepressant Inhibits uptake of 5-HT, NE, blocks DA
Clomipramine Dibenzazepine Antidepressant Inhibits uptake of 5-HT, NE
Bupropion Beta-phenethylamine 2nd Gen. Antidepressant Weak inhibitor of uptake of NE, 5-HT, DA
Maprotilline Tetracyclic 2nd Gen. Antidepressant Inhibits NE uptake
Mirtazapine Tetracyclic 2nd Gen. Antidepressant 5-HT2, 5-HT3 antag. and alpha2-antag.
Venlafaxine Beta-phenethylamine 2nd Gen. Antidepressant Inhibits NE/5-HTuptake (NSRI)
Trazodone Phenylpiperazine 2nd Gen. Antidepressant Inhibits 5-HT uptake/5-HT2 receptor antag.
Nefazodone Phenylpiperazine 2nd Gen. Antidepressant Inhibits 5-HT uptake/ 5-HT2 receptor antag.
Fluoxetine Arylbutylamine SSRI Sel. inhibits 5-HT uptake (SSRI)
Sertraline Arylbutylamine SSRI Sel. inhibits 5-HT uptake (SSRI)
Paroxetine Arylbutylamine SSRI Sel. inhibits 5-HT uptake (SSRI)
Citalopram Arylbutylamine SSRI Sel. inhibits 5-HT uptake (SSRI)
Fluvoxamine Oxime SSRI Sel. inhibits 5-HT uptake (SSRI)
Reboxetine Arylbutylamine SNRI Sel. NE reuptake inh.
Duloxetine Arylbutylamine NSRI Inhibits reuptake of NE and 5-HT
Doxapram Amide Analeptic Medullary stimulant
Lobeline Alkaloid Analeptic Reflex stimulant
Strychnine Alkaloid Analeptic Glycine antagonist
Pentylenetetrazole Tetrazole Analeptic Medullary stimulant
Caffeine Xanthine CNS stimulant Phosphodiesterase inhib. and P1-(A1) adenosine antag.
Theophylline Xanthine CNS stimulant Phosphodiesterase inhib. and P1-(A1) adenosine antag.
Theobromine Xanthine CNS stimulant Phosphodiesterase inhib. and P1-(A1) adenosine antag.
Amphetamine Beta-phenethylamine CNS stimulant Inc. DA release from central neurons
Methamphetamine Beta-phenethylamine CNS stimulant Inc. DA release from central neurons
Methylphenidate Beta-phenethylamine CNS stimulant Blocks DA uptake
Pemoline Beta-phenethylamine CNS stimulant Inc. DA release from central neurons
Modafanil Misc. CNS stimulant Activates orexin neurons
Phentermine Beta-phenethylamine Anorexic agent Inc. NE release from central neurons
Benzphetamine Beta-phenethylamine Anorexic agent Inc. NE release from central neurons
Phenmetrazine Beta-phenethylamine Anorexic agent Inc. NE release from central neurons
Phendimetrazine Beta-phenethylamine Anorexic agent Inc. NE release from central neurons
Diethylpropion Beta-phenethylamine Anorexic agent Inc. NE release from central neurons
Fenfluramine Beta-phenethylamine Anorexic agent Inc. NE release from central neurons
Sibutramine Beta-phenethylamine Anorexic agent Inhibits NE/5-HT uptake
Mazindol Imidazoline Anorexic agent Inhibits uptake of NE
Orlistat Misc. Anorexic agent Irreversibly inhibits lipase
Morphine Morphine der. Central analgetic agonist Opioid receptor agonism
Hydromorphone Morphine der. Central analgetic agonist Opioid receptor agonism
Hydrocodone Morphine der. Central analgetic agonist Opioid receptor agonism
Codeine Morphine der. Central analgetic agonist Opioid receptor agonism
Nalbuphine Morphine der. Mixed agon-antag analgetic Opioid receptor agonism
Buprenorphine Oripavine Mixed agon-antag analgetic Opioid receptor agonism
Levorphanol Morphinan Central analgetic agonist Opioid receptor agonism
Butorphanol Morphinan Mixed agon-antag analgetic Opioid receptor agonism
Pentazocine Benzomorphan Mixed agon-antag analgetic Opioid receptor agonism
Meperidine Piperidine Central analgetic agonist Opioid receptor agonism
Diphenoxylate Piperidine Antidiarrheal Intestinal opioid agonist
Loperamide Piperidine Antidiarrheal Intestinal opioid agonist
Methadone Diphenylpropylamine Central analgetic agonist Opioid receptor agonism
Levomethadyl acetate Diphenylpropylamine Central analgetic agonist Opioid receptor agonism
Propoxyphene Diphenylpropylamine Central analgetic agonist Opioid receptor agonism
Fentanyl 4-anilidopeperidine Central analgetic agonist Opioid receptor agonism
Sufentanil 4-anilidopeperidine Central analgetic agonist Opioid receptor agonism
Alfentanil 4-anilidopiperdine Central analgetic agonist Opioid receptor agonism
Remifentanil 4-anilidopiperdine Central analgetic agonist Opioid receptor agonism
Methotrimeprazine Phenothiazine Central analgetic Raise pain threshold
Dezocine Aminotetralin Mixed agon-antag analgetic Mixed opioid agonist-antagonist
Tramadol Misc. Central/peripheral analgetic Opioid receptor agonist/peripheral 5-HT/NE uptake inhib.
Nalorphine, Naloxone, Naltrexone, Nalmefene Morphine Der. (blank) Narcotic Antagonism
Created by: kdsimmo1 on 2005-04-10



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