Question | Answer |
most common gynecologic cancer? highest death rate? | uterine, ovarian |
what percent of breast/ovarian CA is heredity? | 5-10% |
features indicating BRCA mutation? (5) | mult cases of early onset breast CA, ovarian CA, breast and ovarian CA in same woman, bilateral breast CA, Ashkenazi Jewish heritage, male breast CA |
most CA susceptibility genes are dominant with ______ penetrance | incomplete |
types of ovarian cancer? (3) | epithelial, germ cell, stromal |
how is ovarian CA dx? 60-75% are dx as stage ___ or ____ | dx is made surgically, III or IV |
pelvic mass characteristics that are LOW RISK | premenopausal, <8cm, normal CA-125, unilateral lesion, rassuring sonography (unilocular, non-complex: cystic only, no ascites) |
pelvic mass characteristics that are HIGH RISK | postmenopausal, >8cm, elevated CA-125, bilateral masses, symptomatic, nonreassuring sonography (multiloculated, complex: solid and cystic, acites) |
pelvic mass mgmt? | observation (if no sxs), surgical therapy (if sxs) |
goal of cytoreductive surgery? | no gross macroscopic dz |
"low risk" stage? surgery alone may be sufficient | stage Ia or Ib, grade 1 or 2 |
all other stages/grades require what? | surgery and CHEMO (6 courses in most cases) |
predictors of outcome of ovarian CA (4) | early stage dz, low grade, age/health of pt, minimal residual dz at the completion of surgery |