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gyn-overian cancer

most common gynecologic cancer? highest death rate? uterine, ovarian
what percent of breast/ovarian CA is heredity? 5-10%
features indicating BRCA mutation? (5) mult cases of early onset breast CA, ovarian CA, breast and ovarian CA in same woman, bilateral breast CA, Ashkenazi Jewish heritage, male breast CA
most CA susceptibility genes are dominant with ______ penetrance incomplete
types of ovarian cancer? (3) epithelial, germ cell, stromal
how is ovarian CA dx? 60-75% are dx as stage ___ or ____ dx is made surgically, III or IV
pelvic mass characteristics that are LOW RISK premenopausal, <8cm, normal CA-125, unilateral lesion, rassuring sonography (unilocular, non-complex: cystic only, no ascites)
pelvic mass characteristics that are HIGH RISK postmenopausal, >8cm, elevated CA-125, bilateral masses, symptomatic, nonreassuring sonography (multiloculated, complex: solid and cystic, acites)
pelvic mass mgmt? observation (if no sxs), surgical therapy (if sxs)
goal of cytoreductive surgery? no gross macroscopic dz
"low risk" stage? surgery alone may be sufficient stage Ia or Ib, grade 1 or 2
all other stages/grades require what? surgery and CHEMO (6 courses in most cases)
predictors of outcome of ovarian CA (4) early stage dz, low grade, age/health of pt, minimal residual dz at the completion of surgery
Created by: rjerome09