Target | Receptor | Response |
heart: SA node; AV node | M2 | decrease HR; ; decrease conduction velocity |
GI tract: glands | M1 | secretion |
sphincters | M3 | relax, except LES, which contracts |
blood vessels (endothelium) | M3 | dilation (via NO/EDRF)--no innervation; no effects of indirect agonists |
adrenal medulla | NN | secretion of epinephrine and NE |
autonomic ganglia | NN | stimulation; net effects depend on PANS/SANS innervation & dominance: SANS in arterioles, veins, sweat glands |
neuromuscular junction | NM | stimulation--twitch/hyperactivity of skeletal muscle |
eye--radial muscle | a1 | contraction--mydriasis |
arterioles (skin, viscera) | a1 | contraction--increase TPR |
prostate | a1 | contraction--urinary retention |
prejunctional nerve terminals | a2 | decrease transmitter release and NE synthesis |
pancreas | a2 | decreased insulin secretion |
heart | B2 | increase HR; increase conduction velocity, conduction velocity, force of contraction |
kidney | B2 | increase renin release |
blood vessels (all) | B2 | vasodilation--decrease TPR |
uterus | B2 | relax--inhibit labor |
pancreas | B2 | increase insulin secretion |
renal, mesenteric, coronary vasculature | D1 | vasodilation--in kidney: increase GFR, RBF, Na+ excretion |
CNS | M1 | excitation |