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OU Autonomic Recptrs

Cholinergic and Adrenergic Receptors

TargetReceptorResponse
heart: SA node; AV node M2 decrease HR; ; decrease conduction velocity
GI tract: glands M1 secretion
sphincters M3 relax, except LES, which contracts
blood vessels (endothelium) M3 dilation (via NO/EDRF)--no innervation; no effects of indirect agonists
adrenal medulla NN secretion of epinephrine and NE
autonomic ganglia NN stimulation; net effects depend on PANS/SANS innervation & dominance: SANS in arterioles, veins, sweat glands
neuromuscular junction NM stimulation--twitch/hyperactivity of skeletal muscle
eye--radial muscle a1 contraction--mydriasis
arterioles (skin, viscera) a1 contraction--increase TPR
prostate a1 contraction--urinary retention
prejunctional nerve terminals a2 decrease transmitter release and NE synthesis
pancreas a2 decreased insulin secretion
heart B2 increase HR; increase conduction velocity, conduction velocity, force of contraction
kidney B2 increase renin release
blood vessels (all) B2 vasodilation--decrease TPR
uterus B2 relax--inhibit labor
pancreas B2 increase insulin secretion
renal, mesenteric, coronary vasculature D1 vasodilation--in kidney: increase GFR, RBF, Na+ excretion
CNS M1 excitation
Created by: PittDave