Question | Answer |
Main structures of the digestive system? | oral cavity
esophagus
stomach
small & large intestine |
Accessory organs | pancreas
liver
gallbladder |
4 layers of the lumen (tubular part of the intestine) | mucosa
submuscosa
muscularis externa
serosa or adventitia |
Mucosa | inner most layer of lumen
interacts with food the most |
Submucosa | connective tissue
also has submucosal plexus |
Submucosal plexus | part of the submucosa that is part of the eneteric nervous system controlling digestion |
Muscularis externa | circulartory muscle (circular and longitudnal smooth muscle)
myentaeric plexus |
Myentaric Plexus | part of the enteric nervou systemt hat controls digestion |
Composition of the oral cavity | mouth and pharynx |
What are the organs of the oral cavity? | mouth
pharynx
salivary glands |
Types of salivary glands | parotid
submandibular
sublingual |
Salivary glands are the first level of what? | chemical digestion using amylases (MAIN source) |
What is in saliva? | Enzymes that help to breakdown and santize foods |
Main enzyme in saliva? | amylase |
Function of the esophagus | moves bolus from oral cavity to stomach |
Swallowing is what and occurs where? | moving the bolus down and in the esophogus |
What are the 3 types of swallowing? | voluntary
pharyngeal
esophageal (larynx causes epiglottis to cover the glottis) |
Peristalsis is what and where does it occur? | waves moving food down
the esophagus |
Gastroesophageal sphincter | connects the esophagus to the stomach |
Example of a disease of the esophagus | gastrointestinal intestinal disease (GERD) |
Is swallowing dependent on gravity? | NO! |
Bolus | cewed food and saliva |
4 main regions of the stomach | cardia
fundus
body
antrum (distal pyloric region) |
Cardia region | GE sphincter |
Fundus | top part |
Antrum (DPR) | bottom; between stomach and SI |
Function of DPR | grinds food and mixes with gastric juices to form chyme |
DPR uses what to move chyme? | peristalsis |
Volume of stomach full and empty? | empty: 50mL
full: 1L |
How much saliva is produced each day? | ~1L |
What percentage of saliva is water? | 99% |
function of saliva? | dissolves and lubricates food |
What does saliva contain? | antibacterial and antiviral components |
What does GERD result from? | gastric acid entering the esophagus |
What are some potential precipitators? | smoking, chocolate, peppermint, alcohol, and peppermint cause sphincter to relax |
If you are prone to GERD, what should you avoid? | precipitating foods and laying down after eating |
Gastric glands of the stomach | cardiac
oxyntic
pyloric |
Cells in glands | neck (mucus) cells
parietal (oxyntic) cells
chief (peptic or zymogenic cells
enteroendocrine cells |
Neck (mucus) cells | mucus forms barrier around tissue to prevent acid harm |
Parietal (oxyntic) cells | secrete acid to activate the enzyme pepsinogen and secretes intrinsic facotr which binds to B12 for absorption |
Chief (peptic or zymogenic) cells | secrete enzymes pepsinongen and breaks down proteins a little but not much |
Enteroendocrine cells | secretes hormones in blood |
Active state of pepsin | pepsinogen |
composition of gastric juice | HCl
enzymes
mucus
intrinsic factor |
Gastric juices are made up of HCl for these reasons | converts pepsinogen to pepsin
denatures proteins
releases nutrients from organic complexes
acts as bacteriocide |
Denaturing of acid proteinss | acid connections become more linear and pepsinogen can cleave in |
Release of organic complexes | form an ionic bond from food to release nutrient |
Enzymes in the stomach | some amylase (not much)
pepsin
lipase |
Mucus | provides about 2mm of pr?otection from acid |
Why is there amylase in the stomach? | it travels with the saliva |
What limited chemical digestion takes place in the stomach? | -initiation of protein synthesis
-limited continuation of starch hydrolysis
-absorption of water, alcohol, and a few drugs and minerals
-HCl important for iron and IF for B12 |
What is HCl important for? | iron |
What is IF (intrinsic factor) important for? | B12 absorption |
Hormones and peptide that INHIBIT gastric secretion. | PYY, GIP, secretin, somatostatin |
Hormones and peptides that STIMULATE gastric secretion. | gastrin releasing peptide
gastrin
HCl |
What is the release of HCl stimulated by? | gastrin, acetylcholine, histamine |
Cause of peptic ulcers | H. Pylori |
Treatment of peptic ulcers | H2 blocker= (pepcid/zantac) antagonize signals of histamine
OR
Proton Pump Inhibitors: (priolosec) inhibit HCl by binding receptor |
H. Pylori | bacteria that's acid resistant and a cause of peptic ulcers |
What can disrupt the mucus barrier? | aspirin, alcohol, ibuprofen, |
The small intestine was made to do what? | maximize surface area to increase absorption |
Structural aspects of SI | folds of Kerckring
Villi
microvilli
brush border
crypts of Lieberkuhn |
Folds of Kerckring | large circular folds of mucosa |
Villi | at the end of the folds of Kerckring;
finger-like projections |
Microvilli | hair-like extensions of the cells' plasma membranes |
Crypts of Lieberkuhn | in between villi and replace the old villi |
Enterocytes in the SI are replaced? | every 3-5 days
they are slothed off and digested, which from that, the nutrients are used to make a new one! |
What is the relaxation reflex of the stomach? | controlled by vagud nerve |
Some people use a ____ to control contractions | pacemaker |
What causes ____ contractions that move from fundus to antrum? | myoelectric complex complex; wave-like |
What is the release of chyme regulated by? | volume and osmolarity |
Overall gastric emptying takes how long? | 2-6 hours |
When chyme leaves the stomach it goes where? | through to the pyloric sphincter |
The SI is the main site of what? | digestion and absoption |
What are the sections of the small intestine? | duodenum
jejunum
ileum |
What increases intestinal secretions and motility? | vasoactive intestinal polypeptide (VIP)
neuropeptide substance P, Motlin, CCK |
Where are vasoactive intestinal polypeptides found? | in neurons within the gut |
What decreases intestinal secretions and motility? | PYY, secretin, glucagon-like peptides |
What are the 2 tissues that help to protect the GI tract? | MALT (mucus)
GALT (gut) |
What is the pancreas? | ductless endocrine cells that secrete hormones into the blood |
The pancreas contains what type of enzymes? | digestive that are produced by acinar exocrine cells |
Pancreatic juices contain | bicarbonate
electrolytes
pancreatic digestive enzymes |
Contractions of the SI | segmentation and peristaltic waves |
Segmentation | alternating contractions of circular smooth muscles, which breaks down and mixes intestinal contents |
Peristaltic waves | progressive contractions that move SI contents distally though the SI and toward the LI |