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Pharm II - Week 7
Anticancer Drugs
Question | Answer |
---|---|
Cancer is a group of disorders characterized by (list 4) | 1) rampant growth of invasive cells, 2) lack of feedback mechanism r/t growth, 3) metastasis, 4) immortality |
Cancer can occur due to activation of ____ or inactivation of ___, d/t (list 5) | Oncogenes; tumor suppression genes; UV, x-rays, radiotopes, drugs, viruses |
The primary difficulty of anticancer drugs is... | The effect of drugs on normal fast-growing tissues |
Cancer drugs interrupt the cell cycle at different points. List the cellular phases: | G1 phase - gap phase/undergoes growth. S phase - DNA synthesis. G2 phase - cap phase, prepares for cell division. M phase - mitosis. (G0 is resting phase) |
True or false: solid tumor cells are slower/have low growth factor than leukemias | True |
Most cancer drugs _____ affect high growth fraction | Nonspecifically |
List four normal cell types that have high growth fraction | Hair, GI epithelium, bone marrow blood cells, sperm forming cells |
True or false: once there is less cancer, the drug dose can be adjusted to a lower amount | False. Must keep doses high to kill every cancer cell |
With solid tumors, drug Tx is given in combination with... | Surgery and radiation |
When normal cells grow faster than cancer cells, _____ _____ therapy is done | Intermittent drug therapy |
True or false: when used in combination, drug doses can be smaller | True |
Combination drug therapy's advantages: | Generally more effective than single drug. Less drug resistance, increased killing of cancer cells, less impact on normal cells if drug selections cause different toxicities |
True or false: combination drug therapy has more adverse effects and is more lethal | False. More AE but less lethal |
Bone marrow contains these types of cells and have these AE | RBC, WBC, platelets. Anemia, infection, bleeding |
_____ build RBC, ______- build WBC, ___ build platelets | Epogen/erythropoetin, Neupogen/filgrastim, Neumega/oprelvekin |
GI cells have these AE. You would premedicate with | AE: N/V/D, stomatitis, dehydration, decreased food intake. Premedicate with Zofran/ondansetron, antidepressants, Marijuana, diet supplements |
Sperm cells' AE and support offered | Mutagenesis. Sperm/egg bank prior to Tx and contraception |
Cancer drugs given IV have ______ potential. Which means.... | Vesicant. When given IV, can kill surrounding tissues if leak out of vein. Vasoconstriction --> tissue necrosis |
Carinogenesis means... | More likely to develop other cancers in lifetime |
Erythropoietan is also known as... | Epogen/Procrit |
Epogen is given via these routes and nurse should be aware of these SE | SQ/IV. Painful injection. Hypersensitivity, seizures, HTN |
When treating a pt. with low RBC production, do the following RN actions: | Check fatigue, monitor O2 (NOT sat O2), safety, lab values to measure outcomes |
True or false: when pt. has leukopenia, with bacterial infections will only display fever as symptom | False. Can show only fever with infections of all kinds. |
Treat leukopenia with ______ via ___ (route). SE include | Filgrastim/Neupogen. SQ/IV, nausea, hypersensitivity |
To manage leukopenia: | Prevent infection/handwash, avoid crowds and contact, vigilant temp checks @ home |
Pt. with thrombocytopenia is at danger of __ & __. Treat with this drug via __ (route). Major AE is ____ | Bleeding and hemorrhage. Tx with oprelvekin/Neumega. |
Nursing considerations with oprelvekin | No NSAIDs/anticoagulants. Monitor for bleeding everywhere. Precautions (soft toothbrush). Safety |
Common cause of non-adherence with cancer drugs is ____ (side effect) | Severe diarrhea |
To Tx GI SE, you would... | Provide antiemetic (Zofran/ondansetron), antidepressants, antianxiety (lorazepam, Ativan), marijuana, diet supplements |
True or false: pt. with Hx of cancer often immediately develop another cancer | False. Usually happens many years later |
What drug category is used to treat vesicant drug effects? | Vasodilators (particularly alpha antagonist) |
True or false: most agencies require RNs to have special training to give cancer drugs | True |
When handling anticancer drugs, what should a RN do for protection? | Consistently glove, wear eye/face protection |
Anticancer drugs cannot be given if what is too low? | Blood components |
The most common category of drugs used to cancer is... | Cytotoxic drugs |
List subcategories of cytotoxic drugs and their corresponding meds | 1) antimetabolites (methotrexate), 2) alkylating (cytoxan), 3) antitumor antibiotics (streptomycin), 4) mitotic inhibitors (vincristine) |
Methotrexate is given... and has what indications? | PO/IV. Ectopic pg, severe autoimmune diseases, skin, cancer |
Other AE of streptomycin include... | Cardiomyopathies, dysrhythmias |
True or false: vinblastine spares bone marrow and can cause neuropathies in extremities | FALSE. Vincristine does this. Vinblastine is a completely different drug |
The least toxic category of anticancer drugs: _____ | Hormones and hormone antagonists/blockers |
True or false: hormone/hormone antagonists are more selective in targeting cells | True. See: breast, cervix, uterus, prostate |
What is the mechanism of action for hormone drug Tx? | Suppress production of hormone or block receptors for hormone that is supporting tumor's growth |
List subcategories for hormone/hormone blockers | 1) glucocorticoids, 2) antiestrogens, 3) SERMs (selective estrogen receptor modulators), 4) anti-androgens, 5) progestins |
Glucocorticoids at a high dose will suppress ___ | Lymphocytes |
GCs are indicated for ___, _______, and ___ | Leukemias, Hodgkins, lymphomas |
Tamoxifen is a ____, which blocks ________ | Antiestrogen/SERM, block estrogen receptors |
True or false: SERMs can stimulate estrogen receptors | True. Some can also block estrogen R. |
SERMs is used as _____ as well as treatment. | Preventative |
List some good side effects of SERMs | Increased bone density, decreased LDL, increased HDL |
AE of SERMs include | Uterine cancer, thrombophlebitis (DVT) |
Anti-androgens used to treat... | Prostate cancer |
Progrestins are used to _____ and also known as | Suppress uterine cancer; Depo-provera |
CAM is known as _____ and can be used to cure or help with AE of meds | complementary and alternative medicine |