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Pharm toxicities res
respiratory
Question | Answer |
---|---|
pseudophredrine, phenylephrine | hypertension, CNS stimulation/anxiety (pseudophed) |
dextromethorphan | mild opioid effect when used in excess, mild abuse potential |
cromolyn | toxicity is rare |
beta 2 agonist - salmeterol | tremor, arryhtmia |
H1 blocker - diphenhydramine, dimenhydrinate, chlorpheniramine | sedation, antimuscarinic, anti-alpha adrenergic - dry effects, urinary retention |
loratadine, fexofenadine, desloratadine, cetirizine | decreased entrance into CNS |
danazol | weight gain, edema, acne, hirsutism, masculinization, decreased HDL, benign hepatic adenomas, menstrual irregularities, pseudotumor cerebri |
sildenafil, vardenafil | headache, flushing, dyspepsia, impaired blue green color vision, life threatening hypotension if taken with nitrates |
ritodrine, terbutaline | |
mifepristone | heavy bleeding, GI n/v, anorexia, abdominal pain |
HRT | increased risk of endometrial cancer, increased CV risk |
clomiphene | hot flashes, ovarian enlargement, multiple simultaneous pregnancies, visual disturbances |
leuprolide | antiandrogen, n.v |
testosterone (methyltestosterone) | masculinization in female, reduces intratesticular testosterone -> gonadal atrophy, premature closure of epiphyseal plates, increased LDL, decreased HDL |
estrogen | increased risk of endometrial cancer, bleeding in postmenopausal women, clear cell vagina in females exposed to DES in utero, increased risk of thrombi |
C/I of estrogen | ER positive breast cancer history of Dvts |