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DIT sugar and energy
Question | Answer |
---|---|
glucose to glucose 6P | hexokinase/glucokinase |
fructose 6P to fructose 1,6 bisphosphonate | PFK1 |
PEP to pyruvate | pyruvate kinase |
3 important enzymes of glycolysis | hexokinase/glucokinase, PFK1, pyruvate kinase |
glycogen phosphorylase deficiency | McArdles |
glucose 6P def | Von Gierke's |
Lactic acidosis, hyperlipidemia, hyperuricemia | Von Gierke's |
alpha 1,6 glucosidase deficiency | Cori |
alpha 1,4, glucosidase deficiency | Pompe |
cardiomegaly | Pompe (infantile) |
diphragm weakness causing respiratory failure | Pompe (adult) |
increasd glycogen in liver, severe fasting hypoglycemia | von gierke |
hepatomegaly, hypoglycemia, hyperlipidemia (nL kidneys, lactate, and uric acid) | Cori |
Painful muscle cramps, myoglobinuria with strenuous exercise | McArdle |
sever hepatosplenomegaly, enlarged kidneys | Von Gierke |
m biopsy shows elevated glycogen, fructose 6P, and decreased pyruvate. | deficiency in PFK1 |
what enzyme is responsible for increasing intracellular levels of fru 2,6 bisP | PFK2 |
what enzyme is responsible for decreasing intracellular levels of fru2,6bisP | FBP2 |
how will levels of fru2,6bisP change in the liver and muscle during a sympathetic response? | decrease in the liver, increase in the muscle |
common cause of glycolytic enzyme def | pyruvate kinase deficiency, phosphoglucose isomerase deficiency |
clinical presentation of glycolytic enzyme def | hemolytic anemia due to inability to maintain Na/K ATPase causing RBC swelling and lysis |
Why are alanine and glutamine found in such high concentrations in the blood | They are the 2 major carriers of nitrogen from tissues |
What is required by all aminotransferases | pyridoxal phosphate (a B6 derivative) |
alanine + alphaKG ---> glutamate + pyruvate | ALT |
glutamate + oxaloacetate ---> alpaKG + aspartate | AST |