click below
click below
Normal Size Small Size show me how
DIT musculoskeletal
Question | Answer |
---|---|
zona occludens | tight junction |
prevents diffusion across paracellular space | zona occludens |
compsed of claudins and occludins | zona occludens |
zona adherens | intermediate junction |
just below zona occludens | zona adherens |
cadhereins connect to actin | zona adherens |
calcium dependent adhesion molecules | cadherins |
macula adherens | desmosome |
small discrete sties of attachment | macula adherens |
cadherins connect to intermediate filaments | macula adherens |
pemphigus vulgaris | macula adherens/desmosome |
allows adjacent cells to communicate for electric and metabolic functions | gap junctions |
keratin | mactula adherens |
connects cells to underlying extracellular matrix | hemidesmosome |
bullous pemphigoid | hemidesmosome |
integrins | hemidesmosome |
maintains integrity of basement membrane | integrin |
binds to laminin in basement membrane | integrin |
where does new bone formation take place in growing long bones? | epiphyseal plate |
football player kicked in the leg ahs a damaged medial meniscus. What else is likely messed up? | ACL and MCL = unhappy triad |
initial 15 degrees of arm abduction | supraspinatous |
lateral rotation of arm | infraspinatus/teres minor |
medial rotation of arm | subscapularis |
head of humerus rotates out of glenoid cavity | dislocated shoulder |
clavicle separates from acromion and coaracoid process of the scapula | separated shoulder |
damaged in anterior shoulder dislocation | axillary n, post circumflex a, supraspinatous tendon |
contains only thick fibers | H band |
contains only thin fibers | I band |
actin | thin |
myosin | thick |
never changes | A band |
smaller during contraction | I band |
Reversible when vit d is replaced | osteomalacia/rickets |
excess osteoclastic activity results in disorganized bony architecture | pagets |
bone is replaced by fibroblasts, collagen, and irregular bony trabeculae | polyosteitis fibrous dysplasi |
soft bones due to defective mineralization of osteoid | osteomalacia/rickets |
failure of bone resorption causing thickened and dense bones | osteopetrosis |
genetic deficiency of carbonic anhydrase II | osteopetrosis |
Alk Phos is very elevated, everything else is normal | pagets disease |
most common malignant primary bone tumor of children | osteosarcoma |
most common malignant primary bone tumor in adults | multiple myeloma |
most common benign bone tumor | osteochondroma |
11;22 translocation | Ewing's sarcoma |
soap-bubble appearnace on x ray | giant cell tumor (osteoclastoma |
Onion skin appearance of bone | Ewings |
May actually be a hamartoma | osteochondroma |
codman's triange on x ray | osteosarcoma |
associated with gardner's syndrome | osteoma |
knee pain and swelling, subcutaneous nodules around joins and achilles tendon, pain in the MTP joint of big toes. needle like crystals on biopsy | Gout |
treatment of acute gout exacerbation | NSAID, colchicine, steroids |
difficulty swallowing, distal cyanosis in cold temperatures, and anti-centromere antibodes. What else would you see in this pt? | (CREST scleroderma) + calcinosis, sclerodactyly, telangiectasias |
photosensitivity, arthritis, renal disease, recurrent oral ulcers on primaquine and NSAIDS. What type of check up should she get twice a year? | Lupus. check for nephropathy. Proteinuria, creatinine, dsDNA |
Blood test to confirm Lupus | anti dsDNA antibodies. ANA as a screen |
bilateral hilar lympadenopathy | sarcoidosis |
acute knee pain and swelling. absesnse of erosion. calcium in the menisci. | Pseudogout = calcium pyrophosphate crystals |
Hyperkeratosis, sebum overproduction, propionibacterium proliferation, inflammation | acne |
pruritic, purple, polygonal papules | lichen planus |
life threatening rash with bulla | pemphigus vulgaris/ steven johnson/ TEN |
pruritis a/w asthma | atopic dermatitis (eczema) |
pruritic vesicles a/w celiac disease | dermatitis herpeteformis |
allergy to nickel | allergic contact dermatitis (type 4 HS) |
thickened scar, esp. around face/chest | keloid |
abs against epidermal basement membrane | bullous pemphigoid |
abs against epidermal cell surface | pemphigus vulgaris |
parakeratotic scaling | psoriasis |
keratin-filled cysts | sebhorric keratosis |
sand-paper; predisposition to squamous cell cancer | actinic keratosis |
skin rash and proximal muscle weakness | dermatomyositis |
honey-crusting lesions common about the nose an d lips | impetigo |
hyperkeratosis and koilocytosis | verrucae with HPV |
histology shows palisading nuclei | basal cell carcinoma |