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DIT endocrine quiz
Question | Answer |
---|---|
DM a/w obesity | type II |
DM that may cause ketoacidosis | type I |
DM with strong genetic predisposition | type II |
DM a/w HLA DR3 and 4 | type I |
Parathyroid, Pancreas, Pituitary | MEN I |
Med Thyroid, Pheochromocytoma, Parathyroid | MEN IIa |
Med Thyroid, Pheochromocytoma, Mucosal neuromas | MEN IIb |
Clinical manifestations of Addisons | hyperpigmentation, hypotension, hyperkalemia, acidosis, weakness, malaise, anorexia, weight loss. |
decreased aldosterone, decreased cortisol, increased ACTH | addison's |
adrenal atrophy, absence of hormone production, all 3 cortical divisions | addison's |
lactic acidosis is a rare but worrisome side effect | metformin |
most common side effect is hypoglycemia | sulfonylureas |
MOA: closes K channel on beta cells cause depolarization causing Ca influx cause insulin release | sulfonylureas |
MOA: inhibits alpha glucosidase at intestinal brush border | alpha glucosidase inhibitors |
MOA: agonist at PPARgamma receptors | glitazones |
mech of propylthiouracil? | inhibit the coupling and organificatio of iodine, decrease the peripheral conversion of T4 to T3 |
What other drug works like PTU | methimazole |
Side effects of PTU/methimazone | skin rash, agranulocytosis, aplastic anemia |
What cell type produces PTH? | chief cells of the parathyroid |
What cell type produces calcitonin | C cells (parafollicular) of the thyroid |
What cancers are a/w RET gene mutation? | MEN IIa, IIb, medullary and papillary thyroid carcinoma |
sx of 21 alpha hydroxylase deficiency? | hyperkalemia, hypotension, masculinization |
sx of 11 beta hydroxylase deficiency? | HTN, masculinization |
increased cortisol | Cushing's |
increased aldosterone | Conn's |
decreased cortisol, decreased aldosterone | Addison's |
increased thyroid hormones | Graves' |
extremely tender thyroid gland | DeQuervain's |
palpation of single thyroid nodule | toxic thyroid adenoma |
palpation of multiple thyroid nodules | multinodular toxic goiter |
recet study using IV contrast dye (iodine) | Jod-Basetow phenomena |
Eye changes: proptosis, edema, injection | Graves |
most common chronic arrhythmia | A Fib |
most comon bacteria in GI tract | bacteroides |
most common gynecologic malignancy | endometrial carcinoma |
most common primary cardiac tumor in children | rhabdmyosarcoma |
most common breast cancer | infiltrating ductal carcinoma |