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Phys3 Adrenal Glands
Question | Answer |
---|---|
What hormone is produced in the glomerulosa layer of the adrenal cortex? | mineralcorticoids (Aldosterone) |
What enzyme is specific ONLY to the golomerulosa layer of the adrenal cortex? | CYP11B2 |
Why can't the glomerulosa layer of the adrenal cortex produce gluccocorticoids or catecholamines? | there is NO CYP17 |
What hormone is produced in the fasiculata layer of the adrenal cortex? | Gluccocorticoids (cortisol) |
What hormone is produced in the reticularis layer of the adrenal cortex? | Androgens (testosterone, estradiol) |
Feedback regulation of ACTH | Glucocorticoids feedback inhibit the hypothalamus release of CRH & the pituitary's release of ACTH from corticotrophs as well as their receptors for CRH |
What is the major Protein allowing ACTH to activate steroidogenesis in the fasciculata & reticularis layer? | STAR, it allows cholesterol to enter into the mitochondria. |
Why is streoid hormone release slower than aa or peptide hormone release? | aa or peptide hormones are stored in granuales and released from the cell when the membrane bound receptor is activated. Steroid hormones must be synthesized via DNA transcription which takes more time. |
Main target receptor of ACTH | GPCR |
What key volume regulating enzyme inhibits ACTH to cease steroid production from the adrenal cortex? | ANP |
What Inhibitory effects does cortisol have on the hypthalamus? | 1.Inh GnRH & LH/FSH release. 2.Inh TSH |
Effects of glucocorticoids on the lungs? | Very important for fetal developemnt and maturation of surfactant. |
Effects of glucocorticoids on bone and [Ca]? | 1.Dec osteoblast fnc. 2.Inc Ca uptake in kidneys. 3.Dec Ca uptake in intestines. |
Effects of glucocorticoids on the skin/muscle | 1.thinning. 2.muscular atrophy. **promoting muscle breakdown |
What effects would hyposecretion of cortisol have on ACTH secretion? | INCREASED secretion b/c there is no negative feedback inhibition of cortisol. ACTH can then build up in the cortex |
Congenital adrenal hyperplasia | Defective STAR genes. Therefore no cholesterol can enter the mitochondria and no corisol will be produced. **Screened for at birth, #1 cause of ambiguous genitalia. |
Primary Hyposecretion of glucocorticoids | Adrenal disease: Adrenal hyerplasia. **Most often Addison's Disease, also can be caused by Tb |
Secondary Hyposecretion of glucocorticoids | Deficiency of ACTH caused by either hypopituitarism or cortisol therapy (causes inhibiton at HPA). |
Key enzyme affected in Congenital Adrenal Hyperplasia: Can't produce Mineralcorticoids or Glucocorticoids | CYP21A2. Progesterone & 17-a-hydroxyprogesterone will then be shunted to androgen pathway. **Will see high levels of Androgens, low levels of gluco & mineralcorticoids. |
Key enzyme affected in Congenital Adrenal Hyperplasia: Can't produce glucocorticoids or Aldosterone, but DOC circulates as a weak mineralcorticoid | CYP11B1. DOC cant be converted to Aldosterone, but it is a weak mineralcorticoid and can be sufficient. Again 17-a-Hydroxyprogesterone will be shunted to Androgen pathway. |
Key enzyme affected in Congenital Adrenal Hyperplasia: Can't produce Androgens or glucocorticoids | CYP17. Cant convert pregnenolone or progesterone to their respective 17-a-hydroxy forms. Everything is shunted down mineralcorticoid pathway. **Will see High Aldosterone, Low cortisol & testosterone. |
Which hormone levels will be low with STAR protein abnormalities? | ALL 3 |
Difference b/w Cushings DISEASE and Cushings SYNDROME? | 1.Disease: specific to hypersecretion of ACTH. 2.Syndome: NON-specific, hypersecretion of glucocorticoids. |
Symptoms of Cushing's Disease | 1.Central obesity, atrophy of arms/legs. 2.Inc in cortisol & glucose in urine. 3.Hypertension & Hyperglycemia. 4.Infertility. |
Primary, secondary, and tertiary stimulators of Mineralcorticoid secretion | 1.AngII. 2.Inc EC [K+]. 3.ACTH |
Effects of aldosterone on kidneys? | 1.Na Reabsorption. 2.H2O reabsorption. 3.K excretion. **Regulates Na homeostasis and thus BP |
2 Main symptoms of HYPERaldosterone | 1.Hypertension. 2.Alkalosis |
What stimulates Adrenal Androgen production? | ACTH |
Are Adrenal Androgens an important contributor of ciruclating androgen in men or women? | WOMEN |
What are Chromogranains? | Stabalizing granular proteins that are bound to medullary tyrosine catecholamines when they are produced (4:1 EPI:NE). **They stabilize them b/c of their very short 1/2 life. |
What type of SNS fibers do the chromaffin cells in the adrenal medulla recieve? | PREganglionic |
Stimulation of Catecholamine release? | 1.SNS. 2.ACTH. 3.Cortisol. |
How do Adrenal steroid hormones circulate? | bound to: 1.CBG. 2.Albumin. |