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1. Endocrine System
Overview, structures, and functions
Question | Answer |
---|---|
General functions of the endocrine system. | Regulate Metabolism Regulate Growth, Development & Reproductive Regulate homeostasis |
What controls hormone secretion? | Negative Feedback, Nervous system, certain organs |
What are the structures of the endocrine system? | Pituitary, Pineal, Thyroid, Parathyroid(4), Thymus, Adrenal(2), pancreas, testes & overies |
What are the mechanisms of hormone action? | 1) Steroid Hormone 2) Non-steroid hormone |
Steroid Hormone | Enters the target cell and binds with intracellular receptors. |
Non-steroid Hormone | Binds to a receptor at the surface of the target cell, then a second messenger delivers the hormone's message to the cell. |
Types of Hormone Chemistry | *Steroids *Amines *Proteins |
Types of Steroids | Aldosterone, Progesterone, Testosterone, |
Steroids are synthesized.... | From cholesterol |
Types of Amines | Nor-epinephrine, epinephrine, thyroxine |
Amines are synthesized... | from the amino acid tyrosine |
Thyroxine is also know as | T3 T4 |
Types of Proteins, Glycoproteins, & Polypeptides | Insulin and parathyroid hormone |
Pituitary Gland | Releases 8 hormones. 6 from the anterior lobe and 2 from the posterior lobe. |
Pituitary's Anterior Lobe | Is affected by chemicals transported by blood. |
Pituitary's Posterior Lobe | Is affected by nerve impulses sent from the hypothalamus. |
Growth Hormone (GH) | Targets bone and skeletal muscles to promote growth. |
Growth Hormone is regulated by | GHRF and GHRIF |
What increases blood glucose level? | Growth hormone |
Prolactin | Targets mammary tissue to promote milk formation. |
PRLRF & PRLRIF regulates | Prolactin Hormone |
Thyroid Stimulating Hormone | Targets follicular cells of the thyroid to secrete hormones T3 and T4 |
TSHRF | regulates Thyroid Stimulation Hormone |
Adrenocorticotropic Hormone | Targets the adrenal cortex to cause secretion of cortisol. |
ACTHRF regulates | Adrenocorticotropic Hormone |
Follicle Stimulating Hormone | In males- targets seminiferous tubules to promote sperm cell reproduction In Females- targets follicles in ovaries to promote egg development and secretion of estrogen |
What promotes the secretion of estrogen | Follicle Stimulating Hormone |
Luteninizing Hormone | In Males it targets interstitial cells to secrete testosterone. |
Luteninizing Hormone | In Females it promotes ovulation of the egg and secretion of progesterone |
LHRF regulates | Luteninizing Hormone |
Posterior Lobe Hormones | Oxytocin & Antidiuretic hormone |
Oxytocin Hormone | Targets smooth muscles of the breasts and uterus to promote milk release and contractions. |
Antidiuretic Hormone | Targets the kidneys to promote conservation of water in the blood |
Thyroid | Removes iodine from the blood |
Follicular cell | respond to TSH by secreting the thyroid hormone T3 & T4 |
Thyroid Extra follicular cells | secretes calcitonin |
Calcitonin | Decreases the blood calcium level and stimulates osteoblast cells to deposit calcium in bone tissue. |
Parathyroid Glands | All four secrete the hormone parathyroid hormone. |
Parathyroid Hormone | Increases the blood calcium level and stimulates osteoclast. |
Adrenals | Also called Suprarenal Glands |
Adrenal Medulla | Deep portion, secrets the hormones nor-epinephrine and epinephrine. |
Norepinephrine | primarily increases blood pressure other effects; increase heart rate, and metabolic rate |
Epinephrine | Primarily increases heart rate and forces contraction. |
Epinephrine | increases blood glucose level and dilates airways |
Adrenal Cortex | Has 3 zones; Outter zone, Middle Zone and Inner Zone |
Outter Zone | secretes the hormone aldosterone |
Aldosterone | increases sodium re-absorption in the kidneys and increases blood pressure |
Aldosterone | is a mineralcorticoid hormone |
Middle Zone | Secretes Cortisol, which reduces inflammation, increases blood glucose level and fights stress |
Cortisol | is a glucocorticoid hormone |
Inner Zone | Secretes gonadocorticoid hormone which are small amounts of estrogen and other sex hormones |
Pancreas | An endocrine gland and producer of digestive enzymes. |
The endocrine region of the pancreas | Islets |
Pancreatic islets contain 3 types of cells: | Alpha Beta Delta |
Alpha Cells | secrets glucagon, which increases blood glucose level |
Beta Cells | Secretes insulin, which decreases the blood glucose level |
Delta Cells | Secretes somatostation, which is thought to affect glucogon and insulin secretion |
Type I diabetes | "Juvenile onset" a failure of beta cells to secrete insulin |
Type II diabetes | "Adult Onset" a failure of receptors to respond to insulin. |
Long term effects of diabetes | blindness, amputation, stroke, kidney failure |
Signs / Symptoms of diabetes | hyperglycemia, polydipsia, polyuria, & weight loss |
Thymus | Secretes the hormone thymosins. |
Thymosins | a hormone that stimulates T lymphocyte (white blood cells) |
Pineal | Secretes hormone melatonin |
Melatonin | regulates sleep. |
Spermatagium | A large and primitive cell with 46 chromosomes. |
1 Primary spermatocyte | Has 46 chromosomes and begins meiosis. |
2 Secondary spermatocyte | divides and produces two cells each having 23 chromosomes |
4 spermatids | third stage and divides into 4 cells each having 23 chromosomes Then mature and a flagellum is added |
Spermatogenesis Stages | 1 Spermatagonium 1 primary 2 secondary 4 spermatids |
General functions of the male/Female reproductive system | produce sex cells, secrete hormones, and development |
Spermatozoa | a mature sperm cell that has a flagellum and acrosome |
Interstitial cells | located between the seminferous tubules of the testes. Responds to LH by secreting testosterone |
Sustentacular Cell | Population of protective cells located in the seminferous tubules. Assists and protects developing sperm cells. |
Testes | secretion of testosterone by intersitial cells |
Epididyms | stores sperm cell site at which sperm acquire motility. |
Vas deferns | ductus diferens |
vas deferns | stores mature sperm cells; transports sperm from the epididyms to the ejaculatory duct |
ejaculatory duct | transports mature sperm from the vas deferns to the urethra |
seminal vesicles | produce a fluid that contains the sugar fructose; the energy source for the sperm cells |
prostate | produces a fluid that has a slightly basic (alkaline) pH to protect sperm cells |
cowper's (bulbourethral) glands | provide a fluid that contains mucus to protect sperm cells |
urethra | site of blending of components of semen; transports semen to the exterior of the body |
Oogonium | large primitive cell with 46 chromosomes |
J- shaped tubular structure positioned above each testis | Epididymis |
{aired male gonads which contain seminiferous tubules and interstitial and sustentacular cells | Testes |
paired tubular structures extending from the epididymis to the ejaculatory duct | Vas-Deferns |
narrowed passageway extending from vas defernes to the urethra | ejaculatory duct |
Areas within the penis | Corpora cavernosa (paired structures which fill with blood during erection) and the corpora spongiosum which contains the urethra |
oocytes | the female gamete (eggs) |
Ovaries | site of oogenesis and ovulation of the secondary oocyte |
primary oocyte | 46 chromosomes |
zygote | a fertilized egg, has 46 chromosomes |
Ovarian follicular cells | secrete estrogen in response to FSH |
Following ovulation the corpus luteum secrets | progesterone in response to LH |
Uterine Tube | Transport the secondary oocyte to the uterus and is the site of fertilization |
uterus | site of implantation, growth, and development of an embro |
Menstrual Cycle | Average 28 days |
Phases of the menstrual cycle | Menstrual Period Pre-ovulation Post-ovulation |
The time in which ovarian follicles respond to FSH by enlarging | Menses |
Pre-Ovulatory Phase | follicles enlarge and secrete estrogen endometrium thickens |
Ovulation | releases the 2nd oocyte on aprox day 14 |
progesterone secretion by the corpus luteum causes the endometrium to thicken | Post Ovulatory phase |