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Phys Lect 18
Question | Answer |
---|---|
Pre and Post synaptic Neurotransmitters of the Parasympathetic NS | ACh is used at both of the synapses |
Pre and Post synaptic Neurotransmitters of the sympathetic NS | ACh is the Presynaptic Neurotransmitter in the sympathetic chain. Norepi is the neurotransmitter used by the post synaptic neuron. |
Parasympathetic ACh receptors | 1.Nicotinic: Located in the ganglia on Postsynaptic dendrites. 2.Muscarinic: Located in effector organ. |
Main N receptor Antagonist (Anticholinergic) | Hexamethonium. Blocks parasympathetics all over the body at the ganglion before the postsynaptic neuron. |
Main M receptor Antagonist (Anticholinergic) | Atropine. Blocks parasympathetics at the end organ so therefore can be administered locally. |
Agonists that mimic ACh | Cholinergic 1.Nicotine act like ACh for N receptors. 2.Muscarine act like ACh for M receptors |
Sympathetic Receptors | 1.Nicotinic: On the postsynaptic dentrites in the sympathetic chain or at a ganglion (**Also blocked by Hexamethonium). 2.Adrenergic: on target organ, binds Epi/Norepi. |
Chromaffin cells | Located in the adrenal Medulla. Have ACh Nicotinic receptors on them and receive presynaptic sympathetic. **These cells are responsible for Epi/Norepi mass release into the blood stream (release PRIMARILY EPI). |
Where will Norepi be released from? Epi? | Norepi: Postganglionic neurons. Epi:Adrenal Medulla |
Alpha Adrenergic receptors | Agonist: 1.Norepi > Epi. 2.Phenylephrine. Antagonists: 1.Phentolamine |
Beta Adrenergic receptors | 1.B1 agonists: Epi=Norepi. 2.B2 agonists: Epi >>> Norepi |
Antagonist for all 3 Beta adrenergic receptors | Propanolol |
Where are Beta3 Adrenergic receptors found? | Adipose cytes: encourage lipolysis in the presence of agonist for the creation of energy for bodily use. |