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Pharm chapter 17
Drug Dependence and Addiction
Question | Answer |
---|---|
Disulfiram | inhibits aldehyde dehydrogenase, preventing metabolism of acetaldehyde |
Naloxone | short half-life, competitively blocks binding of opioids to the mu-opioid receptor |
Naltrexone | competitively blocks binding of opioids to the mu-opioid receptor, sustained-release form available |
Methadone | synthetic opioid agonist that binds and activates mu-opioid receptor |
Buprenorphine | partial mu-opioid receptor agonist and kappa-opioid receptor antagonist |
Acamprosate | homotaurine analog, GABAergic agonist, stimulates inhibitory GABAergic neurotransmission in the brain and antagonizes the effects of glutamate, active at postsynaptic GABA-B receptors but not at GABA-A receptors in vitro |
Desipramine | inhibit reuptake of 5HT and NE from the synaptic cleft |
Fluoxetine | Selectively inhibit reuptake of 5HT from the synaptic cleft |