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Renal 08 Gen.Ren.Pat
Leonard: General renal pathology and Basic lab considerations
| Question | Answer |
|---|---|
| Gerota's Fascia | Covers the kidney (not the sinus) Important in staging of tumors |
| Glomerular endothelial cells are... | Fenestrated Allows for easier filtration |
| Principle Kidney Functions | 1. Form and excrete urine 2. Regulate body water 3. regulate electrolytes and mineral content 4. maintain acid-base balance |
| Principle Kidney Function (cont.) | 5. Regulate BP -intravascular vol -vascular tone 6. Regulate erythropoiesis 7. Synthesize active Vit. D |
| Kidney receives __% of total cardiac output | 20-25% |
| Renal plasma flow (RPF) | 600 mL/min |
| Autoregulated PF: Angiotensin | Vasoconstriction Decreases flow |
| Autoregulated PF: Prostaglandins | Vasodilation Increases flow |
| How to classify kidney disease | 1. Renal compartment involved -Glomerular -Tubulointerstitial -Vascular 2. "Focality" (1° V 2°) 3. Acute V Chronic |
| How to classify kidney disease (cont.) | 4. Clinical manifestations -Acute V chronic injury/failure -Nephrotic/nephritic -Hematuria |
| Light microsocopy stains: Silver Trichrome PAS | S: glomerular filtration barrier T: too much extracellular material P: certain types of protein deposited normally |
| Glomerular Filtration: The GFB | 1. Endothelial cells 2. GBM 3. Visceral podocytes 4. Mesangial cell 5. Mesangial matrix No GBM bewteen 1 & 4 |
| The GBM provides a _____ barrier. | Major charge-exclusion barrier |
| Podocyte filtration slit diaphragms acts as the ______ barrier | Primary size-exclusion barrier |
| Pathologic alterations in glomerular disease | 1. Cellularity 2. GFB alterations 3. Hyalinosis 4. Sclerosis |
| Pathologic alterations in glomerular disease: Cellularity | Increased number of cells Inflammation and proliferation |
| Pathologic alterations in glomerular disease: GFB alteration | Deposition of electron-dense material Increase synthesis of GBM/ECM components |
| Pathologic alterations in glomerular disease: Hyalinosis | Insudation of plasma proteins in capillary/vessel wall from endothelial injury |
| Pathologic alterations in glomerular disease: Sclerosis | Accumulation of E/C collagens in mesangium or capillary loops |
Created by:
bcriss
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