click below
click below
Normal Size Small Size show me how
Heart Failure Drugs
Ch. 22 Pharm
Question | Answer |
---|---|
What is automaticity? | Property of specialized excitable tissue that allows self-activiation through the spontaneous dev of an action potential, as in the pacemaker cells of the heart. |
What is positive chronotropic? Negative chronotropic? | increase of heart rate decr of heart rate |
What is + dromotropic? what is - dromotropic? | + = accelerate conduction - = deccelerate conduction |
What is + inotropic? what is - inotropic? | + = incr. force of contraction - = decr. force of contraction |
What is left ventricular end-diastolic volume? Also known as? | Total amt of blood in vent. immediately before it contracts Preload |
what is ejection fraction? what is normal %? | proportion of blood that is ejected during ea vent contraction 65% |
Systolic dysfunction is inadequate ventricular contraction or refilling? | contraction diastolic dysfunction is inadequate vent filling |
Name two typical cardiac defects that lead to heart failure | Myocardial Infarction and Valve deficiency |
Name three defects outside the heart that leads to heart failure | diabetes coronoary artery disease pulmonary hypertension |
What are supraventricular dysrhythmias? | problems in the atria: atrial fibrillation, flutter |
heart failure drugs that are most common positive inotropic drugs? | phosphodiesterase inhibitors cardiac glycosides B-type natriuretic peptids ACE inhibitors ARB's (angiotensin II receptor blockers) beta blockers |
ACE inhibitors do what? | convert angiotensin I to II, a vasoconstrictor and induces aldosterone secretion. Prevents Na and H2O resportion by inhibiting aldosterone secretion. |
What does aldosterone do? | stimulates Na and H2O resportion, can raise BP |
What is renin? | vasoconstrictor released by kidneys |
what is the renin-angiotensin-aldosterone system? | process to raise BP by reorption of Na and h20 |
What is the most common ACE inhibitor? | lisinopril (Prinvil, Zestril) |
What are three ARB's available? | valsartan, candesartan, losartan |
What is an adverse effect of lisinopril? | dry cough, hyperkalemia |
What is the advantage of ARB's over ACE ihnibitors? | no cough |
What do ARB's ultimately do? | vasodilators which decr systemic vascular resistance or afterload |
What are B-type natiurectic peptides and name one | used in severe life threatening heart failure. vasodilators, incr CO, suppress renin-angiotensin system, diuresis nesiritide (Natrecor) |
What do beta blockers block? | SNS stimulation to the heart adn heart's conduction system. Prevent catecholamine actions on heart. |
What is the most common beta blocker? | Metoprolol |
catecholamines are what? | SNS neurotransmitters: epi, norepi, dopamine |
Name 4 adverse effects for B-type natiurectic peptides | hypotension, dysrhythmia, headache, abd pain |
phosphodiesterase inhibitors (PDI's)inhibit what? What is inodilators? Name two drugs | phosphodiesterase inodilators +inotropic,vasodilation inamirone, milirone |
phosphodiesterase inhibitors are given when pxt does not respond to what? | digoxin, diurectics, &/or vasodilators short term mgmt for heart failure |
What are adverse effects of inamrinone? milrinone? | thrombocytopenia (dec platelets) dysrhythmia, hypokalemia, hypotension |
Cardiac glycosides are oldest cardiac drugs. Obtained from what plant? | foxglove |
what is prototypical cardiac glycoside? What treatment is it used for? | Digoxin systolic heart failure, atrial fibrillation |
Digoxin has a + intotropic or - without an increase in what? + or - dromotropic? What does it prolong? | + inotropic, w/o incr in O2 consum. - dromotropic refractory period (area b/n SA & AV nodes) |
What is result of digoxin? | reduced cardiac heart rate and improved cardiac effeciency, reduced heart size, less edema, incr coronary circulation (more blood to heart), help pxt exert and breathe better |
A normal ventricle squeezes how much blood out with how much blood left behind? Weak left vent? | 60%, 40% 33%, 67% |
Heart Failure symptoms | SOB, feet swell, no energy, insomnia, abd swell, cough, diuresis, confusion |
Dig adverse effects | very narrow therapeutic window, can get toxic quickly, drug levels must be .5-2ng/mL Low K incr toxicity electrolyte levels monitored dysrhythmias, headaches, colored vision, anorexia |
What is the antidote for dig overdose? | Digoxin immune Fab (digibind) |
In measure the apical pulse for Dig, what should you look for? | Measure apical for 1 min. If <60 or lower, or >100, then withhold dose and notify doctor |
What food should not be adm. with Dig? | high fiber foods b/c fiber binds and alters absorption adn bioavailability |
Therapeutic effects of pos. inotropic drugs | incr urinary output decr edema decr dyspnea/crackles decr fatigue resolve paroxysmal noct. dyspnea Impr. peripheral pulses,skin color, temp |
What are the parameters for weight gain with heart failure drugs | 2+ lbs in day or 5+ in week, report |
When adm. inamrinone or milrinone, how should you adm. it? | use infusion pump |
An IV inamrinone should never be mixed with what? What color is the solution? | dextrose yellow |