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Test1GeneticsWK-1
Introduction to medical Genetic
Question | Answer |
---|---|
Down syndrome is a chromosome disorder of which chromosome? | Extra copy of Chromosome 21 |
Give two examples of a single-gene defect. | Cystic Fibrosis Sickle cell anemia |
What is one example from the power point of a Multifactorial inheritance genetic disorder? | Alzheimer's Disease |
What are 3 classification of Genetic Disorders? | 1. Chromosome Disorders - Down Syndrome 2. Single-Gene defects ex. Sickle cell Anemia 3. Multifactorial Inheritance - ex. Alzheimer's disease |
What is a unit of genetic information encoded in the DNA? | Gene |
Alleles are what kind of versions of a gene? | Alternative |
What is term refers to as; position occupied by a gene on a chromosome? | Locus |
What are 2 types of chromosomes? | 1. Autosomes - nuclear chromosomes other then the sex chromosomes 2. Sex Chromosomes - XY or XX |
Humans have how many pairs of nuclear chromosomes referred to as Autosomes? | 22 |
When are chromosomes most visible? | 1. Metaphase or 2. Prometaphase |
How are chromosomes distinguished? | Chromosomes are distinguished by their length and the location of the centromere |
What is the study of the structure of chromosomes and their inheritance? | Cytogenetics |
What type of cell division produces 2 daughter cells, each with genes identical to the parent cell | Mitosis - Somatic cell division 46 Chromosomes |
What type of cell division produces gametes? | Meiosis - Germline cell division 23 chromosomes |
During the cell cycle what 3 phases happen during the interphase? | G1 - phase S - phase G2 - phase |
What phase during the cell cycle does replication of each chromosome of one chromatid form 2 sister chromatids that attached at the centromere? | S-Phase Takes 6-8 hours |
How many stages are there in Mitosis? | 5 |
Name the five stages of Mitosis. "My 5 Toes-is are near PP-MAT" | Prophas - Chromosome condensation Prometaphase- nuclear membrane breaks Metaphase- Chromo align Anaphase- Chromo separate at Centromere Telophase- Chromo decondense and nuclear membrane starts to reform around 2 daughter nuclei |
In meiosis 1 (reduction division), in what phase could a possilble error occur "nondisjunction"? | Anaphase 1 - this is the when Disjunction occurs and 2 members of each bivalent move to opposites poles of cell (random assortment of homologues). non-disjunction is possible and would cause an error. |
What phase in not involved b/t Meiosis 1 and 2? | S-Phase |
How long does Spermatogenesis take? | 64 days |
Oogenesis: Primary oocytes remain arrested in Prophase 1 until when? | Ovulation |
Oogenesis: Meiosis 2 proceeds to metaphase during ovulation and is only completed if what occurs? | Fertilization by sperm. |
Deoxyribonucleic Acid (DNA) has 4 base, which two make up the Prrimidine bases and whcih two make up the Purine bases? | Pyrimidine bases: Thymine & Cytosine Purine bases - Adenine & guanine C & G / T & A |
Ribonucleic Acid (RNA) also has 4 bases, but one of the pyrimidine bases is different, which one changes? | Thymine (DNA) changes to Uracil (RNA) and bind with A - Adenine C & G / U & A |
RNA Transcription and RNA processing and splicing happen in the nucleus or cytoplasm? | Nucleus |
RNA Translation and protein assembly process occur where in the cell? | Cytoplasm |
A codon contains how many base sequences? | Condon = 3 base sequence |
Transcription synthesis occur in what direction? | Synthesis occurs in a 5' to 3' direction. Remember that 5' end is considered to be the "PROMOTER" and regulates the initiation of transcription. |
What is "Central Dogma" of molecular Biology? | DNA > RNA > Protein |