Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

KAT PHR 49

Antivirals

QuestionAnswer
Anti herpes drugs typical mechanisms activated by kinases, inhibit polymerase
Acyclovir is derived from guanosine
Acyclovir is used for HSV and VZV
Acyclovir mechanism of action (2) DNA polymerase inhibition, chain termination
Acyclovir is not effective against TK – strains
Acyclovir is excreted via renal
Acyclovir toxicity (2) renal and CNS
Valacyclovir is a longer lasting acyclovir
Penciclovir blocks polymerase DOES NOT terminate chain
Famciclovir is a prodrug activated in liver
Docosanol is a alchohol, inhibits HSV and plasma envelope fusion
Ganciclovir derived from guanine
Ganciclovir mechanism chain termination, DNA polymerase block
Ganciclovir used for CMV how intraocular implant for retinitis
Ganciclovir toxicity is Bone marrow suppression, systemic, leukopenia, thrombocytopenia
Cidofovir mechanism inhibit DNA polymerase, does not require kinase
Cidofovir toxicity nephrotoxic
Foscarnet toxicity nephrotoxic, CNS effects
HSV drugs (4) acyclovir, valacyclovir, penciclovir and famciclovir (-cyclovir)
CMV drugs (4) Ganciclovir, valganciclovir, cidofovir, foscarnet (-gangcylcovir)
Anti Hepatitis drugs interferon, adefovir-dipivoxil, entecavir, lamivudine and ribavirin
IFN a mechanism activates RNAase, degrades RNA
Anti hepatitis drug mechanisms inhibit polymerase
IFN a toxicity myalgia, depression, alopecia, flu like
Adefovir toxicity lactic acidosis, renal tox, hepatic tox
Ribavirin toxicity teratogen, anemia
Anti influenza drugs amantadine, rimantadine, oseltamivir, zanamivir
Amantidine and rimantadine mechanism block M2 protien channel
oseltamivir and Zanamivir mechanism inhibit neuraminidase
oseltamivir toxicity GI
Zanamivir toxicity bronchospasm in asthma
NRTI means nucleotide reverse transcriptase inhibitor
NRTI mechanism inhibit reverse transcriptase after phosphorylation
NRTI examples abacavir, didanosine, emtricitabine , -ine
Zidovudine toxicity bone marrow suppression
Abacavir toxicity hypersensitivity
Didanosine toxicity pancreatitis
Stavudine and zalcitabine toxicity peripheral neuropathy
NNRTI means non nucleoside reverse transcriptase inhibitor
NRTI are metabolized by P450, hepatic
NNRTI mechanism inhibit reverse transcriptase w.out phosphorylation
NNRTI examples (4) delavirdine, efavirenz, etravirine, nevirapine
Delavirdine and nevirapine toxicity rash, liver enzyme elevation
Efavirenz toxicity teratogen
Protease inhibitors mechanism inhibit protein processing
Protease inhibitor examples atazanavir, darunavir,( -navir)
Indinavir toxicity kidney stone, hyperbilirubinemia
Amprenavir toxicity rash
Atazanavir, fosamprenavir, lopinavir, nelfinavir, saquinavir toxicity GI distress
Atazanavir toxicity peripheral neuropathy
Enfuvirtide mechanism block membrane fusion
Maraviroc mechanism CCR5 receptor antagonist
Enfuvirtide toxicity hypersensitivity
Maraviroc toxicity joint and muscle pain, diarrhea, liver enzymes high
Created by: asindhidude
Popular Physics sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards