Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

AssessmentTxAnemia

lecture 13 shen

QuestionAnswer
3 basic mechanisms causing anemia 1) bleeding // 2) decreased RBC production (hypoproliferation of marrow) // 3)premature red cell destruction (hemolysis)
sideroblast nucleated RBC containing granules of Fe in its cytoplasm
sx of anemia pallor, fatigue/weakness, palpitations/CP, SOB/DOE, dizziness, H/A
(ab)nl values of MCV normocytic = 80-100 fL // macrocytic = > 100 fL // microcytic = < 80 fL
With chronic blood loss, RBCs are produced normally until all iron stores have been depleted, after which they become progressively more microcytic and hypochromic, and the reticulocyte response abates.
schistocytes RBC fragments, "tear drops," spur cells, etc
Howell-Jolly bodies nuclear fragments that weren't extruded and persist in RBCs peripherally
Heinz bodies oxidized Hgb that precipitates out in RBCs
Pappenheimer bodies iron granules within RBCs that imply the cells have taken up excess amts of Fe
thalasssemias usually display very low MCVs as well as target cells
serum ferritin usually reflects what? whole body iron stores with high fidelity, hardly ever falsely low EXCEPT in acute inflammation or in some malignant conditions or liver dz
ferroportin the only cellular Fe exporter in vertebrates; present in macrophages, duodenum, hepatocytes and placenta
hepcidin "master modulator of Fe metabolism" - modulates this by inactivating ferroportin and stopping Fe from exiting cells. levels will be LOW in Fe-deficiency anemia but HIGH in anemia of chronic dz
what one expects to find on blood smear of pt with macrocytic anemia macrocytic, possibly oval-shaped RBCs; hypersegmented PMNs ( > 5 lobes)
EtOH can suppress bone marrow as well as providing empty calories that might drive one into folate or B12 deficiency
the commonest form of childhood leukemia and what it's characterized by on CBC with diff ALL, acute lymphoblastic leukemia; characterized by many many blasts or immature lymphocytes with high N/C ratios, usually with suppression of other precursors like plts and RBCs
G6PD deficiency in 15% of AfA men, causes hemolytic anemia with characteristic bite and blister cells as well as Heinz bodies (precipitated Hgb) due to oxidative stress on cells
substance that binds RBC breakdown products in the blood (would be low or non-existent level in pt with hemolytic anemia) haptoglobin
Created by: sirprakes
Popular Medical sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards