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Immunology Cytokines
Cytokines for exam
| Question | Answer |
|---|---|
| IL-1 is secreted by? | Monocytes/activated macrophages |
| IL-2 is secreted by? | CD4+ T-cells (Th-1) |
| IL-4 is secreted by? | CD4+ T-cells (Th-2) |
| IL-5 is secreted by? | Th-2 |
| IL-6 is secreted by? | T cells (Th-2) and macrophages |
| IL-7 is secreted by? | Hassel Corpuscles, Thymic cortical epithelial cells, Bone Marrow Stromal |
| IL-8 is secreted by? | Activated macrophages |
| IL-12 is secreted by? | Activated macrophages |
| IL-13 is secreted by? | TH-2 |
| IFN-alpha is secreted by? | All cells; higher levels in monocytes and fibroblasts |
| IFN-Beta is secreted by? | All cells; higher levels in monocytes and fibroblasts |
| IFN-Gamma is secreted by? | All cells but main source are T cells (CD4 Th1) and NK cells |
| TNFα is secreted by? | Many cell types especially activated macrophages |
| TNFβ is secreted by? | T (Th-1)and B cells |
| CC are secreted by? | Many cell types (neutrophils, B and T cells, etc) |
| CXC are secreted by? | Many cell types (neutrophils, B and T cells, etc) |
| Effects of IL-1? | Fever/pyrogen, Induction of adhesion proteins & APCs, Increase vascular permeability, Autocrine (on macrophage and monocytes), T-cell activation & helps it secrete IL2, B cell proliferation |
| Effects of IL-2? | Autocrine (on CD4), “Growth factor” of various cells (need Ag), Prolif/diff of T,B, or NK cells, Part of inflammatory subset secreted by Th1 |
| Effects of IL-4? | Critical for B cell activation and prolif, Class switching (IgM to IgG,A,E..), Induces Naïve CD4+ into Th-2, Part of helper subset secreted by Th2 |
| Effects of IL-5? | Part of helper subset secreted by Th2, Important for the activation of eosinophils |
| Effects of IL-6? | Fever, B-cell proliferation, Part of helper subset secreted by Th2, Helps produce MBP |
| Effects of IL-7? | T/B cell prolif during development, Needed in culture systems (outside Thymus) |
| Effects of IL-8? | Chemotactic for neutrophils, Increase vascular permeability |
| Effects of IL-10? | Induces Naïve CD4+ into Th-2 |
| Effects of IL-12? | Activates NK cells, Induces Naïve CD4+ into Th-1 |
| Effects of IL-13? | B-cell proliferation, Part of helper subset secreted by Th2 |
| Effects of IFN-alpha? | Induce antiviral state (all), Activate NK cells (all) |
| Effects of IFN-Beta? | Induce antiviral state (all), Activate NK cells (all) |
| Effects of IFN-gamma? | Induce antiviral state (all), Activate NK cells (all), Stimulate macrophage activation, Class switching IgG (subclass 2 &3), Part of inflammatory subset secreted by Th1 |
| Effects of TNFα? | Fever, Chemotactic, Increase vascular permeability, Directly kill tumor cells, Activate moncytes/macrophages, Expression of adhesion molecules |
| Effects of TNFβ? | Directly kill tumor cells, Activate moncytes/macrophages, Expression of adhesion molecules, Part of inflammatory subset secreted by Th1 |
| Effects of TGFβ? | Induces Naïve CD4+ into Th-1, a T-cell factor |
| Effects of CC? | Attract monocytes and T cells |
| Effects of CXC? | Attract neutrophils (same as IL8) |
Created by:
fportugal
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