click below
click below
Normal Size Small Size show me how
Cytokines Day 2
Day 2
Question | Answer |
---|---|
FEVER/ACUTE PHASE CYTOKINES/PYOGENS SECRETED BY MONOCYTES AND MACROPHAGES | IL-1, IL-6, TNF-ALPHA |
3 CHEMOTACTIC FACTORS FOR NEUTROPHILS | IL-8, C5a, LEUKOTRIENE B4 |
INDUCES DIFFERENTIATION OF T CELLS INTO TH1 CELLS | IL-12 |
ACTIVATES NK CELLS | IL-12 |
MIEDATES SEPTIC SHOCK | TNF-ALPHA |
STIMULATES T CELLS (HELPER AND CYTOTOXIC) | IL-2 |
STIMULATES BONE MARROW | IL-3 |
STIMULATES IgE AND IgG | IL-4 |
STIUMLATES IgA AND EOSINOPHILS | IL-5 |
FUNCTIONS LIKE GM-CSF | IL-3 |
INHIBITED BY CYCLOSPORINE AND TACROLIMUS (DRUGS) | IL-2 |
ACTIVATES MACROPHAGES AND TH1 CELLS; SUPPRESSES TH2 CELLS | IFN-GAMMA |
INHIBITS ACTIONS OF ACTIVATED T CELLS AND TH1; SECRETED BY REGULATORY T CELLS | IL-10 |
PLACES UNINFECTED CELLS IN AN ANTIVIRAL STATE BY INHIBITING VIRAL PROTEIN SYNTHESIS | IFN ALPHA AND BETA (DEGRADES VIRAL mRNA) |
PROMOTES B CELL GROWTH AND DIFFERENTIATION | IL-4, IL-5 |
PRODUCED BY TH1 CELLS | IL-2, IFN GAMMA |
PRODUCED BY TH2 CELLS | IL-4, IL-5, IL-10 |
which recombinant cytokine is used to treat hepatitis b and c, kaposi's sarcoma, leukemias, and malignant melanoma? | alpha-interferon |
which recombinant cytokine is used to treat MS? | beta-interferon |
which recombinant cytokine is used to treat chronic granulomatous disease? | gamma-interferon |
which two recombinant cytokines are used to treat thrombocytopenia? | oprelvekin (IL-11), and thrombopoietin |
which two recombinant cytokines are used to treat bone marrow loss in chemo? | filagrastim (granulocyte colony stimulating factor) and sargramostim (granulocyte-macrophage colony stimulating factor) |
which recombinant cytokine is used to treat anemias (esp in renal failure and chemo) | erythropoietin (epoietin) |
which recombinant cytokine is used to treat renal cell carcinoma and metastatic melanoma? | aldesleukin (IL-2) |