Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Cancer drugs dit

DIT cancer drugs

QuestionAnswer
Forms a complex between topoisomerase II & DNA etoposide (Inhibits topoisomerase II)
Alkylates DNA, toxicity - pulmonary fibrosis, hyperpigmentation Busalfan
Fragments DNA. tox=pulmonary fibrosis, skin changes bleomycin (MOA: induces free radicals- breaks DNA strands)
blocks purine synthesis, metabolized by xanthine oxidase 6-mercaptopurine
cross-links DNA, nephrotoxic, ototoxic Cisplatin & carboplatin
nitrogen mustard, alkylates DNA cyclophosphamide
folic acid analog that inhibits dihydrofolate reductase methotrexate
prevents microtubule disassembly (stabilizes) Paclitaxol
intercalculates DNA, produces oxygen free radicals, cardiotoxic doxorubicen & daunorubicin
DNA alkylating agents used in brain cancer nitrosoureas (carmustine, lomustinem, semustine, streptozocin)
Prevents microtubule assembly Vincritine & Vinblastine
Inhibits thymidylate synthase--> decreased nucleotide synthesis 5-fluorouacil
SERM - blocks estrogen binding on ER (+) cells tamoxifen, raloxifene
MOA similar to antiviral acyclovir & foscarnet cytarabine (MOA: inhibits DNA polymerase)
MOA similar to fluoroquinolones Etoposide (MOA: inhibits tomoisomerase II)
MOA similar to trimethoprim Methotrexate - folic acid analog that inhibits dihydrofolate reductase
monoclonal antibody against HER-2 (erb-B2) Trastuzumab
free radical induced DNA strand breakage Bleomycin, Doxorubicin, Daunorubicin
inhibitor of PRPP synthetase 6-mercaptopurine
reversible with leucovorin methotrexate (reverses myelosuppression)
treatment for choriocarcinoma methotrexate
treatment for testicular cancer Etoposide-teniposide, bleomycin, cysplatin ("eradicate ball cancer")
applied topically for AKs & basal cell cancer 5-fluorouracil
treatment for childhood tumors (Ewing's, wilm's, rhabdomyosarcoma) dACTinomycin. MOA: intercalculates DNA
inhibits ribonucleotide reductase hydroxyurea
SE of hemorrhagic cystitis cyclophosphamide
antibody against philadelphia chromosome Imatinib
Side effects of prednisone Cushing-like symptoms, immunosuppression,k cataracts, acne, HTN, osteoporosis, insomnia, psychosis, peptic ulcers
Created by: nissaali
Popular USMLE sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards