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Block II drugs- UND
Question | Answer |
---|---|
Ibuprofen class | NSAID |
Ibuprofen action | competitively inhibits COX1&2 and is slightly more selective for COX-1. These enzymes catalyze the reaction of arachidonic acid to prostaglandin |
Methotrexate class | antineoplastic |
Methotrexate action | antimetabolite, Methotrexate competitively and reversibly inhibits dihydrofolate reductase (DHFR); Folic acid is required for DNA synthesis. |
Prednisone class | corticosteroid |
Prednisone action | suppress inflammation and the normal immune response, induce apoptosis of lymphocytes |
Nitroglycerin class | Nitrate Vasodilator |
Nitroglycerin action | Relaxation of vascular smooth muscle causes peripheral pooling |
Imitrex class | Vascular headache suppressant |
Imitrex action | Selective agonist at specific vascular serotonin receptors causing vasoconstriction in large intracranial arteries |
Prostoglandin E1 class | ductus arteriosus patency adjuncts |
Prostoglandin E1 action | Directly relaxes smooth muscle of the ductus arteriosus; Temporary maintenance of patent ductus arteriosus |
Dobutamine class | β1-Adrenergic agonist |
Dobutamine action | Selective β1-Adrenergic agonist (leads to increased myocardial contractility and increased stroke volume with modest increase of heart rate) |
Atenelol class | antiadrenergics, B-blocker |
Atenelol action | selective B1-receptor antagonist, thus heart rate and contractility are decreased |
Oxycodon class | analgesic, narcotic |
Oxycodon action | opioid receptor agonist; to hyperpolarization and decreased activity of neural cells |
Aspirin class | NSAID |
Aspirin action | irreversibly inhibits cyclooxygenase (COX 1 & 2); decrease prostaglandin synthesis |
Simvastatin class | antihyperlipidemic |
Simvastatin action | inhibit HMG-CoA reductase; increase LDL receptors |
Acetaminophen class | non-narcotic analgesic, antipyretic |
Acetaminophen action | Act on hypothalmic heat regulating center for antipyresis, elevates pain threshold |
Norepinephrine class | Vasoconstrictor |
Norepinephrine Action | a1- adrenergic receptor agonist, leads to Ca2+ release from ER causing vascular smooth muscle contraction |
Norepinephrine uses | Life threatening hypotension not caused by hypovolemia. Nasal decongestant |
Clonidine class | Sympatholytic |
Clonidine action | a2 adrenergic agonist; inhibits vasomotor center in medulla oblongata reducing sympathetic activity |
Clonidine uses | Tx of HTN |
Prazosin class | Alpha-blocker |
Prazosin action | a1 adrenergic antagonist; reduces NE/E binding to a1 receptors in vasculature causing vasodilation |
Prazosin uses | Tx. HTN |
Captopril class | ACE inhibitors |
Captopril action | Inhibits angiotensin converting enzyme (ACE) reducing production of angiotensin II (a direct vasoconstrictor); Inhibits degradation of bradykinin enhancing production of vasodilatory prostaglandins. |
Captopril uses | Tx. of HTN |
Losartan class | Angiotensin receptor blocker (ARBs) |
Losartan action | Antagonist at Angiotensin type I receptor. (more complete inhibition of Ang II effects than ACE inhibitors) |
Losartan uses | Tx. of HTN, CHF |
Why ARB over ACE inhibitor | No cough because bradykinin degraded |
Nifedipine class | Calcium channel blocker |
Nifedipine action | Block the inward flow of Ca 2+ into vascular smooth muscle cells, reducing their contractility |
Nifedipine uses | Tx. of HTN, vasospastic angina, arrhythmias |
Nitroglycerine uses | Tx. and prophylaxis of angina, tx of CHF, and MI (decreases preload and afterload) |
Name 4 Diuretics | Furosemide (loop), acetazolamide (carbonic anhydrase inhibitor), hydrochlorothiazide (thiazide), spironolactone (potassium-sparing) |
Diuretic action | Increase renal excretion of Na+ and thus the equivalent amount of water. (reduces plasma volume and venous return) |
Diuretic uses | Tx. of HTN, edema, CHF, renal failure |
Isoproterenol Class | Beta adrenergic agonist |
Isoproterenol action | B1 and B2 agonist; Increases cAMP and activation of Ca2+ channels. Increases HR, conduction rate, contractility |
Isoproterenol uses | (b1) Cardiogenic shock, heart failure; (b2) asthma, emphysema |
Dobutamine class | Beta adrenergic agonist |
Dobutamine action | B1 agonist Increases cAMP and activation of Ca2+ channels. Increases HR, conduction rate, contractility |
Dobutamine uses | (b1) Cardiogenic shock, heart failure |
Terbutaline class | Beta adrenergic agonist |
Terbutaline action | B2 agonist; bronchodilator and increase cAMP leading to Increases HR, conduction rate, contractility |
Terbutaline uses | Bronchodilator for asthma and emphysema |
Milrinone class | Phosphodiesterase inhibitor |
Milrinone action | Inhibit phosphodiesterase which degrades cAMP |
Milrinone uses | Tx. of heart failure |
Dopamine class | Dopamine agonist |
Dopamine action | Activate Dopamine receptors in renal, mesenteric, cerebral vasculature causing vasodilation. Dopamine is a precursor for NE which causes vasoconstriction |
Dopamine uses | Dose dependent. Low doses <10 ug/kg/min vasodilate, large doses vasoconstrict |
Digoxin class | Cardiac glycosides |
Digoxin action | Directly inhibit Na+/K+ ATPase, increasing intracellular Na+ reducing the transmembrane Na+ gradient, inhibiting Na+/Ca2+ exchange and thus reducing Ca+2 flux out of myocytes |
Digoxin uses | Heart failure |
Propanolol class | Beta-blocker |
Propanolol action | Antagonist at B1, B2 receptors |
Propanolol uses | HTN |
Name Calcium channel blockers | Nifedipine (most potent vasodilator), Verapamil, diltiazem |
Nifedipine, verapamil, diltiazem action | Block inward flow of Ca2+ during phase 2 (plateau) in cardiac AP, and decreased Ca2+ into vascular smooth muscle leading to decreased cardiac output, peripheral resistance, and increase renal blood flow |
Nifedipine, verapamil, diltiazem uses | HTN |
Levosimendan class | Calcium sensitizers |
Levosimendan action | Increases sensitivity of cardiac troponin to Ca2+ and has vasodilator action |
Levosimendan uses | Heart failure |
Dexamethasone Class | Corticosteroid |
Dexamethasone Action | suppress inflammation and the normal immune response, induce apoptosis of lymphocytes |
Dexamethasone Uses | Respiratory distress, allergies, reduction of inflammation |
Ampicillin Class | Aminopenicillin |
Ampicillin Action | Inhibits bacterial cell wall synthesis |
Gentamicin Class | Aminoglycoside |
Gentamicin Action | Irreversibly binds 30s subunit of ribosome and inhibits bacterial protein synthesis |