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Pain
Question | Answer |
---|---|
ASA MOA | NONSELECTIVE irreversible inhibitor of cox1 |
ASA AE | GI, REYE'S SYNDROME, FLUID RETENTION, bleeding, renal impairment, hypersensitivity reaction |
ASA INTER | EtOH, GLUCOCORTICOIDS, ACE/ARBS. LITHIUM. Drugs that promote bleeding |
ASA Other | Avoid with asthma |
NSAIDS MOA | REVERSIBLE inhibition of COX1 and COX 2 |
NSAIDS AE | GI, HYPERSENSITIVITY REACTION, REYE'S SYNDROME, FLUID RETENTION, PROLONGS BLEEDING TIMES |
NSAIDS INTER | DRUGS THAT PROLONG BLEEDING TIME, EtOH, glucocorticoids, ACE/ARBS, lithium |
Celecoxib MOA | Selective inhibition of COX 2 |
Celecoxib AE | MI, STROKE, Sulfonamide allergy, FLUID RETENTION |
Celecoxib INTER | WARFARIN, EtOH, glucocorticoids, ACE/ARBs, LITHIUM |
Celecoxib OTHER | Does not inhibit platelet aggregation or Bleeding |
Celecoxib Preg | X |
Acetaminophen MOA | inhibits prostaglandin synthesis at the CNS |
Acetaminophen AE | HEPATOTOXICITY, HEPATIC NECROSIS |
Acetaminophen INTER | WARFARIN, EtOH |
Hepatic Necrosis antidote | Actylcysteine |
Morphine MOA | mimics actions of endogenous opioid peptides |
Morphine AE | RESPIRATORY DEPRESSION, ELEVATIONS OF INTRACRANIAL PRESSURE, NEUROTOXICITY, constipation, withdrawal |
Morphine INTER | CNS DEPRESSANTS, ANTICHOLINERGIC DRUGS, ANTIHISTAMINE, MAOIS, LINEZOLID |
Treat Opioid antagonist overdose | Naloxone |
Drug for respiratory depression | Narcain |
Naltrexone | Morphine. black box warning NEPHROTOXICITY |
Fentanyl | Morphine. Short half life |
Tapentoadol MOA | Central opiod agonist. inhibit NE reuptakde |
Tapentoadol AE | RESPIRATORY DEPRESSION, ELEVATION OF INTRACRANIAL PRESSURE. NEUROTOXICITY. SEROTONIN SYNDROME. STEVEN JOHNSON SYNDROME |
Tapentoadol | CNS depressants, MAOI, LInezolid, TCA, SSRI/SNRI |