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Neuropharm drugs

Questions for 3rd year pharmacology course Neuropharm unit, particularly drugs

QuestionAnswer
Lamotrigine Anticonvulsant/mood stabaliser MOA: Sodium channel Inhibition
Amitryptiline TCA Antidepressant SERT/NERT inhibition (uptake-1?)
Phenytoin Anticonvulsant (epilepsy) MOA: Stabilizes the inactive state of voltage-gated sodium channels
Phenobarbitone Barbiturate MOA: Positive allosteric modulator of GABA-A.Rs @ alpha subunit & AMPA.R blocking
Ethosuximide Anticonvulsant (absence seizures) T-type calcium ch. blocker
Sodium Valproate / Valproic Acid / Valproate Anticonvulsant/mood stabilizer(/antidepressant) Only one able to be used for all seizures types & classes. MOA: histone deacetylase inhibitor, inhibition of the transamination of GABA (by inhibiting GABA transaminase), T-type Ca/Na.ch block
Quisqualate Kainate.R agonist?
Rotigotine Antiparkinsonian, Dopamine agonist
Tolcapone COMT inhibitor (to assist L-dopa)
Amantadine Originally antiviral, Dopamine releasing agent, anticholinergic, NMDA.R antagonist
Carbamazepine Anticonvulsant (also mood stabaliser/ADHD/schizophrenia/PTSD) MOA: Stabilizes the inactivated state of sodium channels. MOA:
Primidone Anticonvulsant (Pyrimidinedione class) MOA: Works via interactions with voltage-gated sodium channels which inhibit high-frequency repetitive firing of action potentials
Created by: seeriktus
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