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Chapter 14
Therapeutic Drug Monitoring and Toxicology
Question | Answer |
---|---|
TDM came about in order to help improve the outcome of certain types of drug therapy. Some medications have toxic effects at blood levels only | slightly higher than the therapeutic level. |
Toxicity may cause damage to organs such as | the liver and kidneys. (Hepatotoxicity, Nephrotoxicity) |
Dosage and timing of dosage as well as route of administration, and half life all play a part in | hitting the correct therapeutic level of drug for the patient. |
The half life of a drug is the time it takes for the concentration of | drug to decrease by half. |
If the dose is delivered at every half life the drug should | reach a steady state after 4 to 5 half lives. |
The half life can be effected by each individuals genetic make up and must be determined from | pharmacokinetic calculations. |
Some drugs are measured by the effect on the patient I.E. | PT/INR and coumadin, or Furosemide on blood pressure. |