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Pathology
Path
| Question | Answer |
|---|---|
| Rb1 | retinoblastoma, osterosarcoma, breast, colon, lung (BCL) |
| NF1 | NF1, neuroblastoma |
| NF2 | NF2, menangioma, schwannoma (acoustic) |
| BRCA1/2 | breast (both), ovary (female) |
| APC | stomac, pancreas, colon, familial APC |
| TGF-beta | colon |
| SMAD 2/4 | colon, pancreas |
| E-cadherin | stomach, familial gastric cancer |
| WT1 | Wilms' tumor |
| PTEN | prostate, endometrial, cowden's syndrome |
| p53 | most cancers, Li Fraumani syndrome |
| P16Ink4a | malignant melanoma, pancreas, breast, esophageal |
| LKB1 | Peutz-Jegher |
| VHL | Renal cell carcinoma |
| MEN1 | Multiple endocrine neoplasia 1/2 |
| RET | Multiple endocrine neoplasia 1/2 |
| PTCH | nevoid basal cell carcinoma |
| Defective DNA repair | xeroderma, bloom syndrome, fanconi anemia, ataxia-telangiectasia |
| familiar cancer | breast, ovarian, pancreatic |
| cushings | small-cell, pancreatic, neural tumor (ACTH) |
| SIADH | small-cell (ADH/ANF) |
| Hypercalcemia | squamous cell carcinoma, breast, renal, adult T-cell leukemia/lymphoma (PTH-related protein, TGF-alpha, TNF, IL1) |
| Hypoglycemia | Ovarian, fibrosarcoma (insulin/insulin-like) |
| Carcinoid | hepatocellular, bronchial, pancreatic (serotonin, bradykinin) |
| Polycythemia | gastric, renal, cerebellar hemangioma, hepatocellular (erythrpoeitin) |
| Myasthenia | bronchogenic carcinoma |
| acanthosis nigrican | gastric, lung, uterine (EGF) |
| dermatomyositis | bronchogenic, breast carcinoma |
| trousseau phenomenon | bronchogenic |
| red cell aplasia | thymic neoplasms |
| clubbing of fingers | bronchogenic |
| CA-125 | ovarian |
| CA-15-3 | breast |
| CA-19-9 | pancreatic, colon (P & P = backwards 9-9) |
| hCG | nonseminomatous testicular tumor, trophoblastic tumor |
| calcitonin | medullary carcinoma of thyroid |
| catecholamines | pheochromocytoma |
| alpha-fetoprotein | liver cell cancer, nonseminomatous germ cell tumor of testis |
| CEA | colon, pancreas, lung, stomach, heart |
| neuron specific enolase | small cell carcinoma, neuroblastoma |
| Igs | multiple myeloma |
| PSA | prostate |
| p53, APC, RAS mutants in stool | colon |
| p53/RAS in stool | pancreatic |
| p53/RAS in sputum | lung |
| p53 in urine | bladder |
| rubella | PDA, cataracts, deafness |
| CMV | urine cytology diagnosis, periventricular necrosis & calcification |
| syphilis | pneumonia alba, copius nasal discharge, periostitis |
| herpes simplex | ascending infection, small necrotic lesions |
| coxsackievirus B | myocarditis |
| parvovirus B19 | hyrdrops, RBC inclusions |
| toxoplasmosis | multifocal cereberal calcifications |
| vinyl chloride | liver angiosarcoma |
| arsenic | GI, CV, CNS interference |
| Cadmium | obstructive lung disorder, renal tubular damage |
| mercury | neuromotor, cognitive, behavior disruption |
| benzene | leukemia |
| dioxin | chloracne, skin folliculitis |
| organochlorines | potent endocrine disruption (anti estrogen/androgen) |
Created by:
lamsonma
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