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MACC Kidney & Diseas
MACC Kidney physiology and Diseases
Question | Answer |
---|---|
What is the path of blood in the kidneys? | Renal Artery, Afferent arteriole, peritubular capillaries, vasa recta, efferent arteriole, renal vein |
The peritubular capillaries surround what part of the nephrons? | Proximal and distal convoluted tubules |
The Glomerulus is located within what structure? | Bowman's capsule |
What part of the nephron serves as a nonselective filter of plasma substances? | Gomerulus |
What hormone system controls the flow of blood to and within the glomerulus | Renin-Angiotensin-Aldosterone |
What are some of the compounds that are reabsorbed by the tubules? | Water, sodium chloride, bicarbonate, potassium, calcium, amino acids, phosphate, protein, glucose |
At what level of glucose in the blood is needed to exceed the threshold of a normal kidney? | Serum glucose of 160 - 180 mg/dl |
What part of the tubules is impermeable to water? | Ascending loop of Henle |
What is the creatinine clearance used for? | It is used to determine the extent of nephron damage in known cases of renal disease, to monitor the effectiveness of treatment and to determine the feasibility of administering medications |
What is Polyuria? | Abnormal increase in the volume of urine (>2500ml/24 hrs) |
What is Oliguria? | Decrease in urinary volume (< 500 ml/24 hrs) |
What is anuria? | The complete suppression of urine formation (<100 ml/24 hrs) |
What is cystitis? | Inflammation of the bladder |
What is nephritis? | Inflammation of the kidney |
What is pyelonephritis? | Inflammation of the kidney due to a bacterial infection |
What does "Microalbumin" test for? | It is a quantitative test for small amount of albumin present in urine |
What is the GFR or glomerular filtration rate? | It is the rate of plasma volume cleared by the glomeruli per unit of time (ml/min). |
What are some factors used to calculate the estimated GRF? | Creatinine, age, sex and race |
What two tests should be used to monitor for renal disease? | Microalbumin and eGRF |
What are the functions of the kidneys? | filtration of blood, regulation of acid, water and electrolyte valance, regulation of hormone levels in the blood and removal of waste products and unwanted substances from plasma |
What is acute kidney failure? | Sudden loss of the kidneys to remove waste and concentrate urine without losing electrolytes |
What are some causes of acute kidney failure | Autoimmune, decreased blood flow, infections, pregnancy complications, urinary tract obstructions |
What is glomerulonephritis? | A sterile, inflammatory process that affects the glomerulus. Blood, protein and casts are found in the urine. |
What are the symptoms of glomerular disease? | Proteinuria, hematuria, reduction of GFR, hypoproteinemia |
When is acute poststreptococcal glomerulonephritis seen in a patient? | This disease is seen following a respiratory infection caused by certain stains of group A streptococcus that contain M proteins in the cell wall of the bacteria |
What glomerular disorder is initiated by deposition of immune complexes in the glomerulus, is rapid and progressive? | This disease is rapidly progressive (crescentic) gomerulonephritis. |
What renal disease is caused by the appearance of cytotoxic autoantibodies against the glomerular and alveolar basement membrane after a viral respiratory infection? | This disease is Goodpasture Syndrome |
In what renal disease is there an increase serum level of IgA and immune complexes deposited on the glomerular membrane? | Berger disease or Immunoglobulin A nephropathy |
What are the symptoms of nephrotic syndrome? | Blood and protein in the urine, also fat globulars, oval fat bodies and fatty casts. RTE can also be present |
What is acute tubular disorder? | This disease is caused by damage to the tubule cells of the kidney, resulting in acute kidney failure |
What is Fancoini Syndrome? | This disease is a tubular disorder in which certain substance normally reabsorbed into the bloodstream by the nephrons are released into the urine instead |
What is diabetes insipidus? | This disease is caused by the lack of ADH or antidiuretic hormone |
What is the most common cause of ESRD or End Stage Renal Failure Disease? | Diabetes Mellitis |
What is Melanin? | A pigment which occurs normally in the skin |
Why would melanin be present in the urine? | From a metastatic malignant melanoma excreting excess melanin |
What color would urine contain melanin be? | Urine would be dark brown to black several hours after being voided |
What are porphyrins? | They are complex iron-free cyclic substances which are intermediates in the biosynthetic pathway of heme. |
What are the Watson-Schwartz and Hoesch tests for? | Porphyrins |
What causes dysmorphic red blood cells? | Red blood cells slipping thru the glomerulus - glomerulus bleeding |
What does Aldosterone control? | increases the absorption of sodium and the excretion of potassium |
What does ADH control? | water absorption thru the collecting tubule epithelium |
What is Chronic Renal Failure? | Progressive loss of renal function caused by an irreversible and intrinsic renal disease. |
What are renal stones? | aggregates of solid chemical interlaid with a matrix of protein and lipids |
What is Phenylketonuria? | when phenylpyruvic acid is excreted in the urine due to enzyme deficiency in the pathway to form the amino acid tyrosine |
What is Tyrosinuria? | When tryrosine cannot be metabolized onto important chemicals needed by the body |
What causes Diabetes Mellitus? | Buildup of glucose in the blood and urine due to lack of or impaired insulin causing polyuria |
What is Diabetes Insipidus? | Lack of ADH causing polyuria |
What pathway is blocked in galactosemia? | metabolism of galactose to glucose |