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Quiz 4

drug use/moa/ADEs
Tyrvaya nasal spray for dry eye
VABYSMO monoclonal antibody for AMD
Bevacizumab (Avastin) monoclonal antibody for AMD
Tropicamide (Tropicacyl) Cycloplegics and Mydriatics Muscarinic antagonists do both, Intraocular examination Intraocular surgery Treatment of anterior uveitis
Praluent (alirocumab) lowers LDL choleserol
Repatha (evolocumab) PCSK9 inhibitor
PRADAXA Xa inhibitor
Praxbind® (idarucizumab) PRADAXA reversal agent
Xeralto Xa inhibitor
Andexxa Xeralto reversal agent
Angiotensin-Converting EnzymeInhibitors (ACE) Captopril (Capoten) Uses (oral) Hypertension Heart failure Acute MI– Left ventricular dysfunction– Diabetic and nondiabetic nephropathy– Prevent MI, stroke, death in patients at highrisk for CV events
ACE Inhibitors ADEs First-dose hypotension Cough Hyperkalemia Renal failure Fetal injury Angioedema – Safety Alert
ACE Inhibitors drug inx Diuretics – may intensify 1st dose hypotension Antihypertensive agents – additive hypotensive effect Drugs that raise potassium levels – may increasehyperkalemia Lithium – can accumulate to toxic levels, monitor levels Nonsteroidal anti-inflam
Angiotensin II Receptor Blockers Mechanism of action ARBs block access of angiotensin II Cause dilation of arterioles and veins Prevent angiotensin II from inducing pathologic changes in cardiac structure Reduce excretion of potassium Decrease release of aldosterone Increase
Angiotensin II Receptor Blockers Losartan (Cozaar) Therapeutic uses Hypertension Heart failure Diabetic nephropathy Myocardial infarction Stroke prevention Migraines
Losartan (Cozaar) ADEs Well tolerated Angioedema Fetal harm Renal failure
Aldosterone Antagonists Eplerenone (Inspra) Mechanism of action Selective blockade of aldosterone receptors Therapeutic uses Hypertension Heart failure Pharmacokinetics – 25 & 50-mg tablets Absorption is not affected by food Adverse effects – hyperkalemia
Aldosterone Antagonists Spironolactone (Aldactone) Mechanism of action Blocks aldosterone receptors Binds with receptors for other steroid hormones Therapeutic uses Hypertension Heart failure
Spironolactone (Aldactone) Adverse Effects Hyperkalemia Gynecomastia Menstrual irregularities Impotence Hirsutism Deepening of the voice
Calcium Channel Blockers Prevent calcium ions from entering cells Called calcium antagonists Also called slow calcium blockers Play a critical role with vascular smooth muscle and heart
Verapamil (Calan, Covera-HS, Isoptin, Verelan) Hemodynamic effects Vasodilation Reduced arterial pressure Increased coronary perfusion Therapeutic uses Angina pectoris Primary hypertension Cardiac dysrhythmias Migraine
Created by: kleikamb
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