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Parkinson's Drugs
| Question | Answer |
|---|---|
| What is the On-Off Phenomenon? | A common experience of patients being medicated for Parkinson's disease in which they experience periods of greater symptomatic control alternating with periods of lesser symptomatic control |
| What is wearing off phenomenon or end of dose phenomenon? | A gradual worsening of Parkinsonian symptoms as a patient's medications begin to lose their effectiveness, despite maximal doses with a variety of medications |
| Why can't exogenous dopamine be used to treat Parkinson's disease? What can be used instead? | Dopamine is too large to cross the blood brain barrier, however, levodopa a precursor of dopamine is small enough to cross the BBB |
| Dopa-decarboxylase is an enzyme present in the brain and periphery that breaks down levodopa. What problem does this present? How can this problem be solved? | Dopa-decarboxylase in the periphery often breaks down levodopa before it can reach the brain, requiring higher doses of levodopa. Carbidopa inhibits peripheral dopa-decarboxylase and can be added to levodopa, allowing more levodopa to reach the brain |
| Why shouldn't pyridoxin (vitamin B12) be consumed while on levodopa? | Vitamin B12 promotes the breakdown of levodopa and even reverses its effects. |
Created by:
littlejohnson
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