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Antiepileptic Drugs
Epilepsy and AED
| Term | Definition |
|---|---|
| Felbamate | General Considerations - antagonist of excited neurotransmitters NMDA Receptor antagonist at the glycine site ADR- CNS Depression, Headache, GI, Cognitive/Behavioral Effects, Idiosyncratic, Drug Withdrawal, Teratogenesis (birth defect) |
| Topiramate | General Considerations - antagonist of excited neurotransmitters Kainate/AMPA Receptor Antagonist ADR- CNS Depression, Headache, GI, Cognitive/Behavioral Effects, Idiosyncratic, Drug Withdrawal, Teratogenesis (birth defect) |
| Lamotrigine | General Considerations - antagonist of excited neurotransmitters Inhibition of Glutamate Release ADR- CNS Depression, Headache, GI, Cognitive/Behavioral Effects, Idiosyncratic, Drug Withdrawal, Teratogenesis (birth defect) |
| Valproic Acid (DEPAKENE) Divalproex Sodium (DEPAKOTE) | |
| Carbamazepine (TEGRETOL, CARBATROL) | |
| Oxcarbazepine (TRILEPTAL) | |
| Phenytoin (DIALANTIN) | |
| Fosphenytoin (CEREBYX) | |
| Ethosuximide (ZARONTIN) | |
| Zonisamide (ZONEGRAN) | |
| Benzodia[zepines] - Cholorzepate (Tranxene) - Diazepam (Valium) - Clonazepam (Klonopin) - Lorazepam (Ativan) - MIdazolam (Versed) | MOA: Enhances GABA-mediated synaptic transmission - INC FREQUENCY ADR: Sedation, Lethargy, Tolerance, Behavior |
| Phenobarbital (LUMINAL) | MOA: Enhances GABA-mediated synaptic transmission - INC DURATION Second line of therapy for focal seizures and general tonic-clonic seizures ADR: Sedation, Drowsy, Behavior in Children, LONG Half Life |
| Gabapentin (NEUROTIN) | MOA: INC GABA synthesis Adjunctive Monotherapy for focal seizures Adverse Effects : Fatigue, somnolence, dizzy, ataxia, most common aggressive behavior in children |
| Pregabalin (LYRICA) | MOA: Structural Analog of Gabapentin Adjunct therapy for focal seizures and neuropathic pain |
| Tiagabine (GABATRIL) | MOA: GABA reuptake inhibitor Adjunctive Monotherapy for focal seizures in adults ADR: Mild relative to other AED, Dizzy, Nervous, tremor, Diarrhea |
| Vigabatrin (SABRIL) | MOA: Irreversible inhibitor of the enzyme GABA transaminase Infantile Spasms, Refractory Focal Seizures ADR: Somnolence, Fatigue, Depression, Irreversible field of defect |
| Lamotrigine (Lamictal) | MOA: Prolong Refractory Period Na+ Channel MOA: Inhibit glutamate release Adjunctive Monotherapy for focal seizures in adults ADR: Diplopia, Drowsy, Ataxia, Headache, *Generalized Rash |
| Felbamate (FELBATOL) | MOA: Prolong Refractory Period Na+ Channel MOA: NMDA receptor antagonist Reserved for patients for AEDs ADR: Aplastic Anemia, Dizzy, Fatigue, Insomnia, Headache |
| Topiramate (TOPIRAMAX) | MOA: Kainate/AMPA Receptor antagonist Adjunct Therapy for focal seizures BROAD AED ADRs: Ataxia, Memory, confusion, nephrolithiasis=STAY HYDRATION |
| Rufinamide (BANZEL) | MOA: Prolong Inactivation of NA+ Channel |
| Lacosamide (VIMPAT) | MOA: Slow Inactivation of NA+ Channel Focal onset Seizures ADR: Dizzy, Tremor, Blurred Vision, Little Somnolence |
| Ezogabine (POTIGA) | MOA: Promotes K+ Channels Adjunct for Focal Onset Seizure ADR: Drowsy, Dizzy, Confusion * Rare Urinary Retention |
| Cannabidiol (EPIDIOLEX) | Does not use Cannabinoid ADR: Drowsy, Fatigue, Anorexia, Diarrhea *Transaminase Elevation UNKNOWN |
Created by:
kimi_neria
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