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Serotonin

TermDefinition
Zolmi[triptans] (ZOMIG) Nara[triptan](AMERGE) Riza[triptan] (MAXLT) Almo[triptan] (AXERT) Frova[triptan] (FROVA) Ele[triptan] (RELPAX) Suma[triptan] (IMITREX) Serotonin 5-HT1B/10 Agonist Nerve Terminals & Blood Vessels INDC: Migraine Aborts MOA: Stimulate presynap 5-HT1D - DEC inflammatory neuropeptides ADR - Ergot-containing drugs, MAO inhibs, SSRIs - Fatal Serotonin Syndrome
Ergotamine tartrate (ERGOMAR) Ergotamine Tartrate + Caffeine (CAFERGOT) Dihydroergotamine (DHE, MIGRANAL) Serotonin Ergot Alkaloids 5-HT1B/1D + Alpha Agonist INDC: Migraine Aborts MOA - Antimigraine - effects 5-HT1B, 5-HT1D, A1 Receptors ADR- Nausea and Vomiting, Uterine Smooth Muscle, Ergotism - prolonged vasospasm
Lasmiditians (REYVOW) Serotonin 5-HT1F Agonist INDC: Migraine Aborts MOA: No Vasoconstrictive Effects, penetrates the BBB into CNS
Rime[gepant] (Nurtec) Ato[gepant] (Qulipta) Ubrogepant (Ubrelvy) Serotonin Antagonist - Anti-CGRP INDC: Migraine Aborts MOA: Small CGRP Receptor antagonist
Propanol (INDERAL) Timolol (BLOCADREN) Beta Blockers (1st line) INDC: Migraine Prevention MOA: Block Beta1 receptor ; normalize vascular tone; normalize excessive SNS, anti anxiety
Verapamil (CALAN) Calcium Channel Blockers (ALT) INDC: Migraine Prevention MOA: Reduce influx of Ca++ into presynapse; reduce release of CGRP
Amytriptyline (ELAVIL) Tricyclic Antidepressant (TCA) (1st line) INDC: Migraine Prevention MOA: Block neuronal Na+ channel, Down regulate 5-HT1 receptors, Reduce GABA reuptake into GABA nerve terminals
Botulinum Toxin (BOTOX) Antiepileptic (1st line) INDC: Migraine Prevention MOA - INC GABA Mediated inhibition - Normalize functions of cerebral cortex and trigeminal nerve, Reduce release of CNS excitatory amino acid NT (GLUTAMATE)
Valproic Acid (DEPAKENE Antiepileptic (1st line) INDC: Migraine Prevention MOA - INC GABA Mediated inhibition - Normalize functions of cerebral cortex and trigeminal nerve, Reduce release of CNS excitatory amino acid NT (GLUTAMATE)
Divalproex (DEPAKOTE) Antiepileptic (1st line) INDC: Migraine Prevention MOA - INC GABA Mediated inhibition - Normalize functions of cerebral cortex and trigeminal nerve, Reduce release of CNS excitatory amino acid NT (GLUTAMATE)
Topiramate (TOPMAX) Antiepileptic (1st line) INDC: Migraine Prevention MOA - INC GABA Mediated inhibition - Normalize functions of cerebral cortex and trigeminal nerve, Reduce release of CNS excitatory amino acid NT (GLUTAMATE)
Erenumab (Aimovig) Migraine Prophylaxis New Therapy INDC: Migraine Prevention MOA : Antibodies Block Calcitonin Gene Related-Peptides (CGRP) ADR: Angioedema and allergic reactions
Eptinezumab (VYEPTI) Fremanezumab (AVOJY) Galcanezumab (EMGALITY) Migraine Prophylaxis New Therapy INDC: Migraine Prevention MOA : Antibodies Block Calcitonin Gene Related-Peptides (CGRP) ADR: Angioedema and allergic reactions
Ergonovine (ERGOTRATE) Methylarginine (METHERGINE) Serotonin Ergot Alkaloids Agonist Alpha1-5-HT2 - Postpartum Atony INDC: Prevent and treatment of postpartum atony and hemorrhage MOA: compress uterine blood vessels ADR- Nausea and Vomiting, Uterine Smooth Muscle, Ergotism - prolonged vasospasm
Created by: kimi_neria
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