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Sympatholytic

Blockers, Antagonist, Sympatholegics

TermDefinition
Metyrosine (Demser) Indirect - Affects NE Synthesis INDC : Hypertension due to Pheochromocytoma (Adjuvant/ Alpha Adrenergic Blocking Agent ) MOA: Inhibit Tyrosine Hydroxylase ; deplete catecholamines in SNS, Adrenal, CNS NervTerm ADR:Hypotension, Diarrhea, Congestion
Reserpine (Serpasil) Indirect - Affects NE Synthesis in Vesicles INDC : Hypertension (rare) (Low Dose, combined with diuretics ) MOA: Irreversibly blocks Catecholamine Uptake into Storage Granules ADR: Depletion of Dopamine and Serotonin, Sedation, Depression
Clonidine Methyldopa Guanfacin Guanabenz Indirect Sympatholytic + Sympathomimetic INDC: Affecting NE Release MOA: DEC NE Release
Guanethidine Bretylium Indirect Sympatholytic + Sympathomimetic INDC: Affecting NE Release MOA: Vesicular Fusion Blocker
Phentolamine (Regitine) Nonselective ALPHA1+ALPHA2 INDC: Pheochromocytoma and Hypertensive Crisis INDC: Reverse Toxicity of Alpha agonist INDC: Necrosis Reversible Nonselective A1A2 ANTAGONIST
Phenoxybenzamine (Dibenzyline) Nonselective ALPHA1+ALPHA2 INDC: Hypertension due to pheochromocytoma/sympathomimetic MOA: Block Alpha1 in Arterioles/Veins MOA: Inhibit Vasoconstriction MOA: Lower BP ADR: orthostatic hypertension, congestion
Doxazosin (CARDURA) Prazosin (MINIPRESS) Terazosin (HYTRIN) Selective ALPHA 1 BLOCKERS INDC: Hypertension INDC: BPH MOA: Blocks Alpha 1b, relaxes prostate wall and sphincter ADR: orthostatic hypertension, congestion, no ejaculation, miosis, reflex tachycardia, floppy iris syndrome, priapism **FIRST DOSE
Afluzosin (Uroxatral) Selective ALPHA 1 BLOCKERS INDC: BPH MOA: Blocks Alpha 1b and selectively accumulates in prostate tissue ADR: orthostatic hypertension, congestion, no ejaculation, miosis, reflex tachycardia, floppy iris syndrome, priapism
Tamsulosin (Flomax) Silodosin (Rapaflo) Selective ALPHA 1 BLOCKERS INDC: BPH MOA: Blocks Alpha 1a, lower chance of orthostatic hypotension ADR: orthostatic hypertension, congestion, no ejaculation, miosis, reflex tachycardia, floppy iris syndrome, priapism **MOST SPECIFIC LESS ADR
Yohimebine Selective ALPHA 2 BLOCKERS INDC: Erectile Dysfunction, Hypotension, Weight Loss - MOA: Blocks Alpha2 Receptors- INC NE release ADR: Anxiety, INC BP effect, NE transporter is blocked ~INC BP and HR
Atipamezole (Antisedan) Selective ALPHA 2 BLOCKERS INDC: Reverses analgesia caused by Dexmedetomidine MOA: Blocks Alpha2 Receptors INC ADR: N/A
Propranolol Labetalol Nadolol Carvedilol Sotalol Nonselective BETA (1+2) BLOCKERS [1st GEN] INDC: Hypertension & CHF ADR: Reflex Tachycardia, Hyperkalemia, Libido, Depression, Hypoglycemia
Metoprolol Bisoprolol Esmolol Atenolol Nebivolol Selective BETA1 BLOCKERS [2nd GEN] INDC: Post Surgery ADR: Reflex Tachycardia, Hyperkalemia, Libido, Depression, Hypoglycemia
Acebutolol Propanolol MEMBRANE STABILIZERS [1st GEN] MOA: Inhibits Na+ Channels to Stabilize
Acebutolol Pindolol INTRINSIC SYMPATHOMIMETIC MOA: Partial agonis of Beta Receptors - Asthma
Acebutolol Sotalol POTASSIUM BLOCKERS [1st GEN] MOA: Prolong action potential duration
Carvedilol** Labetalol VASODILATORS 3RD GEN BETA BLOCKERS INDC: Beta Blocker + Alpha1 Antagonist TRIPLE THREAT- Great Antihypertensive Effect but More orthostatic hypotension MOA: Hypertension +CHF ADR: Hyperthyroid, Hyperkalemia, Loss Libido, Depression, HYPER/HYPOGLY
Nevibolol** Carteolol Celiprolol VASODILATORS 3RD GEN BETA BLOCKERS INDC: Beta Blocker + Nitric Oxide Activity MOA: INC No synthesis of Vasodilation MOA: Hypertension +CHF ADR: Hyperthyroidism, Hyperkalemia, Loss of Libido, Depression, Hyper/Hypo-glycemia, NO PHENOCHROMOCYTOMA
Bucindolol Carteolol Celiprolol VASODILATORS 3RD GEN BETA BLOCKERS INDC: Beta Blocker + Beta 2 Agonist activity NO MOA ADR: Hyperthyroidism, Hyperkalemia, Loss of Libido, Depression, Hyper/Hypo-glycemia, NO PHENOCHROMOCYTOMA
Carvedilol** Betaxolol VASODILATORS 3RD GEN BETA BLOCKERS INDC: Beta Blocker + Ca2+ Activity NO MOA ADR: Hyperthyroidism, Hyperkalemia, Loss of Libido, Depression, Hyper/Hypo-glycemia, NO PHENOCHROMOCYTOMA
Timolol** Carteolol Metipranolol Levobunolol Betaxolol GLAUCOMA BETA BLOCKERS INDC: Glaucoma MOA: Treat INC Intraocular Pressure from Glaucoma ADR: Absorption into circulation, Heart and Respiratory ADRs
Phentolamine (Oraverse) Nonselective ALPHA1+ALPHA2 INDC: Reverse Local Anesthesia after Dental Procedure MOA: Block Alpha1 in Arterioles/Veins MOA: Inhibit Vasoconstriction MOA: Lower BP **REVERSIBLE NONSELECTIVE ANTAGONIST
Created by: kimi_neria
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