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DirectSympathomimtic

Directly BIND and STIMULATE Adrenergic Receptors

TermDefinition
Midodrine (Proamatine) ALPHA 1 AGONIST INDC : Orthostatic Hypotension INDC : Maintain BP during Surgery MOA : Vasoconstriction ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Metaraminol (Aramine) ALPHA 1 AGONIST INDC : Hypotension INDC : Relieves Paroxysmal Atrial Tachycardia MOA : Vasoconstriction MOA : Stimulate the release of NE ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Phenyl[ephrine] Hydrochloride (Biorphen) ALPHA 1 AGONIST INDC Hypotension from anesthesia MOA : Vasoconstriction MOA : INC Venous Return MOA : INC BP ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Phenyl[ephrine] (Neosynephrine) ALPHA 1 AGONIST INDC : Cardiac Shock MOA : Vasoconstriction MOA : INC Venous Return MOA : INC BP ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Mephentermine (Wyamine Sulfate Injection) ALPHA 1 AGONIST INDC : Prevent Hypotension INDC : Accompanies Spinal Anesthesia MOA : Act Direct AND Indirect ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Phenyl[ephrine] (Neosynephrine) EYE ALPHA 1 AGONIST INDC : Facilitate Ophthalmic Examination INDC : SEE MORE OF EYE MOA : MYDRIASIS - Contracts Radial Fibers ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Nepha[zoline] (NAPHCON w/ Visine-A) ALPHA 1 AGONIST INDC : Red Puffiness ,Itchy, Watery Eyes due Colds, Allergies, Eye Irritations [1] MOA : Constricts Ocular Blood Vessels ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Oxymeta[zoline] (Visine L.R) ALPHA 1 AGONIST INDC : Red Puffiness ,Itchy, Watery Eyes due Colds, Allergies, Eye Irritations [2] MOA : Constricts Ocular Blood Vessels ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Tetry[zoline] (Visine) ALPHA 1 AGONIST INDC : Red Puffiness ,Itchy, Watery Eyes due Colds, Allergies, Eye Irritations [3] MOA : Constricts Ocular Blood Vessels ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Phenyl[ephrine] (Neosynephrine) NOSE ALPHA 1 AGONIST INDC : Nasal Decongestant [1] MOA : Constrict Nasal Vasculature ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Nepha[zoline] (Privine) ALPHA 1 AGONIST INDC : Nasal Decongestant [2] MOA : Constrict Nasal Vasculature and Mucosa ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Oxymeta[zoline] (Afrin) ALPHA 1 AGONIST INDC : Nasal Decongestant [3] MOA : Constrict Nasal Vasculature and Mucosa ADR : Hypertension, Reflex, Urinary Retention ~Desensitization ~Drug Interactions : MAOI, TCA, BETA BLOCKERS
Clonidine (Catapres) ALPHA 2 AGONIST INDC : Hypertension INDC : Off Labeled ADHD MOA : CNS - Postsynaptic >> DEC SNS Activity MOA PNS - Presynaptic >> DEC NE Release ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Clonidine (Kapvay) ALPHA 2 AGONIST INDC : ADHD MOA : Stimulate Postsynaptic Alpha2 in Prefrontal Cortex MOA : Inhibit Basal Neurons> Improve Cognition, Memory, Behavior, Attention ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Clonidine (Duraclon) ALPHA 2 AGONIST INDC : Pain Management MOA : Dorsal Horn - DEC Neurotransmitter MOA : Brain Stem - DEC NE locally ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Clonidine (Unlabeled) ALPHA 2 AGONIST INDC : Nicotine & Opiate Withdrawal MOA : Activation of Peripheral Presynaptic ALPHA 2 Receptor MOA : DEC Excessive NE Release from SNS Nerves ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Guanabenz (Wytensin) ALPHA 2 AGONIST INDC : Hypertension MOA : CNS - Postsynaptic >> DEC SNS Activity MOA PNS - Presynaptic >> DEC NE Release ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Guanafacine (TENEX, INTUNIV) ALPHA 2 AGONIST INDC : Hypertension MOA : CNS - Postsynaptic >> DEC SNS Activity MOA : PNS - Presynaptic >> DEC NE Release ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes *MORE SELECTIVE THAN CLONIDINE
Methyldopa (ALDOMET) ALPHA 2 AGONIST INDC : Hypertension MOA : CNS - Postsynaptic >> DEC SNS Activity MOA PNS - Presynaptic >> DEC NE Release ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes *Methyldopa = Weak Agonist
Guanfacine (TENEX, INTUNIV) ALPHA 2 AGONIST INDC : ADHD MOA : Stimulate Postsynaptic Alpha2 in Prefrontal Cortex MOA : Inhibit Basal Neurons> Improve Cognition, Memory, Behavior, Attention ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Tizanidine (ZANAFLEX) ALPHA 2 AGONIST INDC : Muscle Relaxant to Treat Spasticity Cerebral and Spinal Disorders MOA : INC Presynaptic Inhibition of Motor Neurons *Similar to Clonidine ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Dexmedetomidine (Precedex) ALPHA 2 AGONIST INDC : ICU Sedation, Procedural Sedation MOA : CNS - Postsynaptic >> DEC SNS Activity MOA : DEC Noradrenergic Neurons in Brain Stem *NO GABA ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Lofexidine (Lucemyra) ALPHA 2 AGONIST (Adrenergic Receptor) INDC : Opioid/Alcohol Withdrawal, Postmenstrual MOA : DEC Excessive NE Release from SNS Nerves *No Effect on Drug Cravings ADR : CNS Depression, Dry Mouth, Sexual Dysfunction, AV Block, Constipation, Dry Eyes
Brimonidine (Mirvaso) ALPHA 2 AGONIST INDC : Treatment for Facial Erythema MOA : Alpha A2 Receptor ; Selective Activation of Blood Vessels leading to Vasoconstriction ADR : Use w/ Caution in Patients w/ Severe CVD
Brimonidine (Alphagan) ALPHA 2 AGONIST INDC : Treat Ocular Hypertension or Open Glaucoma MOA : Alpha A2 Receptor ADR : Hypotension and Sedation (via crossing BBB)
Apraclonidine (Iopidine) ALPHA 2 AGONIST INDC : Reduce Intraocular Pressure, Open Angle Glaucoma - Localized due to being Systemic MOA : Selective Alpha A2 Receptor ADR : (Predictable) Dry Mouth, (Unpredictable) Allergic Conjunctivitis, Visual Disturbances
Dobutamine (Dobutrex) BETA 1 AGONIST INDC : Heart Failure, Cardiogenic Shock MOA : Beta1 Adrenergic Receptor Agonist MOA : Positive Inotropic Effect >> INC Cardiac Output ADR : Desensitization // Down Regulation of Beta1 Receptors *HEART IS SAD IT NEEDS ??? *
Pirbuterol (MaxAir) Albuterol (ProAir, Proventil) Levalbuterol (Xopenex) Metaproterenol (Alupent) BETA 2 AGONIST INDC : Acute Asthma MOA : SABA MOA : Bronchodilation *exercise and quick reliefs ADRS : Worsening Asthma, Glaucoma, Epilepsy, Tachycardia, Hypokalemia, Muscle Tremor, INC BP, Nervousness
Formoterol (Brovana) Arformoterol (Fordil) Salmterol (Serevent) BETA 2 AGONIST INDC : Long Term Prevention of Asthma MOA : LABA MOA : Bronchodilation ADRS : Worsening Asthma, Glaucoma, Epilepsy, Tachycardia, Hypokalemia, Muscle Tremor, INC BP, Nervousness
Vilanterol (Breo Ellipta) Indacaterol (Arcapta) Olodaterol (Striverdi Respimat) BETA 2 AGONIST INDC : Long Term Prevention of Asthma MOA : Ultra-LABA MOA : Bronchodilation ADRS : Worsening Asthma, Glaucoma, Epilepsy, Tachycardia, Hypokalemia, Muscle Tremor, INC BP, Nervousness
Terbutaline (Brethine) BETA 2 AGONIST INDC : Acute Bronchospasms INDC : Prevent Preterm Labor MOA : SABA MOA : Inhibit Premature Contractions ADR : Predictable Arrhythmia, Hypertension Hypokalemia, MI, Tachycardia, Death, Maternal Heart Problems and Death
Mirabegron (Myrbetriq) BETA 3 AGONIST INDC : Overactive Bladder MOA : INC Bladder Capacity by Relaxing Smooth Muscle ADR : Hypertension, Nasopharyngitis, UTIs, Not Metabolized CYP3A4, 2D6, 2C9, Lower BBB Penetration
Vibebegron (Gemtesa) BETA 3 AGONIST INDC : Overactive Bladder MOA : INC Bladder Capacity by Relaxing Smooth Muscle ADR : Hypertension, Nasopharyngitis, UTIs, Not Metabolized CYP3A4, 2D6, 2C9, Lower BBB Penetration
Isoproterenol (Isuprel) Non-Selective BETA AGONIST INDC : Emergency Heart Stimulation MOA : Low affinity for Alpha Receptors MOA : Lower Peripheral Vascular Resistance MOA : INC Cardiac Output ADR : Palpitations, Tachycardia, Headache, Arrhythmia, Flushing
Epinephrene (Adrenalin) Non-Selective ALPHA BETA AGONIST INDC : INC HR INDC : DEC Bleeding MOA: Alpha 1, Alpha 2, Beta 1, Beta, 2 ADR: Cardiac Arrhythmias, Tachycardia, Hypertensive Crisis, Hemorrhage, Tumor, Peripheral Ischemic Areas
Norepinephrine (Levophed) Non-Selective ALPHA BETA AGONIST INDC : Hypotension from Cardiovascular Shock MOA: Alpha 1, Alpha 2, Beta 1 ADR: Vasoconstriction
Fenoldopam (Corlopam) SELECTIVE D1 AGONIST INDC: Acute Severe Hypotension MOA : Vasodilation of Renal and Peripheral Blood Vessels ADR: Hypotension, Tachycardia, Hypokalemia
Bromocriptine (Parlodel) D2 AGONIST INDC: Acromegaly [Hyperprolactinemia, Parkinsonism, Type2] MOA: Pituitary : Inhibit Prolactin, Hypersecretion MOA: CNS : Nigrostriatal, Restore Motor Function ADR: Cardiac Valve and Pleural Fibrosis (unpredicted), MI, Stroke, Seizer
Dopamine (Inotropin) D1, D2, ALPHA1, BETA1 AGONIST INDC: Cardiogenic Shock Low Cardiac Output MOA : Dilates renal coronary/mesenteric arteries LOW: D1 - V.D ; D2 - DEC NE MED: Beta 1 - INC HR HIGH: Alpha 1 - V.C ADR: DEC VC/Cardiac Effects, INC Hypertensive Crisis
Created by: kimi_neria
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