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Pharm 2
Urogenital Drug Therapy
| Question | Answer |
|---|---|
| Which statements regarding the pharmacokinetic parameters of medroxyprogesterone acetate is accurate? | - Food increases the drug’s bioavailability. -Medroxyprogesterone acetate is 90% protein bound. -The drug undergoes hepatic metabolism involving hydroxylation and conjugation. |
| Which formulation of testosterone has the longest elimination half-life? | Intramuscular testosterone cypionate |
| Which phrases accurately describe the mechanism of action and roles of medroxyprogesterone acetate in hormone replacement therapy? | -Protects against endometrial proliferation, which can cause cancer -Causes a transition in the endometrium from the proliferative to the secretory phase |
| Which time frame describes when oral conjugated equine estrogens (CEE) should reach the peak plasma concentration? | 6 to 10 hours |
| Which drugs are type 5 phosphodiesterase (PDE5) inhibitors used to treat erectile dysfunction (ED)? | -Avanafil -Sildenafil -Tadalafil -Vardenafil |
| Which statements accurately describe what occurs normally within the body during an erection? | -During the nonerect state, arterial blood flow into the penis is equal to venous outflow into the body. -Acetylcholine increases the production of nitric oxide from endothelial cells. |
| -- | -Nitric oxide activates guanine cyclase, which produces cyclic guanosine monophosphate. -Cyclic guanosine monophosphate causes smooth muscle relaxation and increases blood flow into the penis. |
| In which time frame can a patient expect sildenafil to begin working? | 30 to 60 minutes |
| Which statement by the nursing student about benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) therapy requires further intervention? | Sildenafil is a 5-alpha-reductase inhibitor that causes smooth muscle constriction, allowing increased blood flow into the penis. |
| Which statement about the pharmacokinetic parameters of finasteride is accurate? | Finasteride is excreted in both the urine and the feces. |
| Which mechanism of action describes how pseudoephedrine works to treat stress urinary incontinence? | Alpha1-adrenergic agonism |
| Which statements regarding the pharmacokinetic parameters of oxybutynin are accurate? | -Gels and patches allow for passive diffusion of oxybutynin across the skin. -Oxybutynin is widely distributed in tissues. |
| -- | -The drug is hepatically metabolized, with most metabolism occurring through CYP3A4. -A small amount of the administered oxybutynin dose is excreted in the urine. |
| Which statement regarding the pharmacodynamics and pharmacokinetics of mirabegron is accurate? | Mirabegron undergoes extensive metabolism that involves CYP2D6 and CYP3A4. |
| Which patient parameters would a nurse ensure are assessed before a female patient begins therapy with oral conjugated equine estrogens and medroxyprogesterone acetate for menopausal symptoms? | -Smoking status -Complete gynecologic history, including if she has an intact uterus -History of or current thromboembolism -Patient and family history of hormone-sensitive cancers |
| Which patient education points are important for a nurse to share with a patient who has been prescribed buccal testosterone 30 mg twice daily? | -The old tablet should be removed before applying a new one. -It may take the drug about 30 seconds for the drug to be applied. -The tablet should be placed above the incisor tooth, adhering to the gum. |
| Which teaching points would the nurse share with a patient who had a hysterectomy and is newly prescribed conjugated equine estrogen (CEE)? | -The patient may experience depressive symptoms or mood changes with CEE therapy. -CEE increases the risk for deep vein thrombosis and stroke and should be used for the shortest amount of time. |
| Which patient education points would the nurse share with a patient who has been prescribed sildenafil for erectile dysfunction? | -The drug will not work without adequate sexual stimulation. -The drug should be administered about an hour before sexual activities. -The patient should report any dizziness, chest pain, or blood pressure changes to the health care provider. |
| A nurse is providing care to a patient with benign prostatic hyperplasia and erectile dysfunction who is receiving both sildenafil and tamsulosin. Which potential outcome may result from the two drugs being taken together? | Hypotension |
| A patient with hyperthyroidism, prostate cancer, type 2 diabetes mellitus, and status post myocardial infarction 9 months ago is in clinic to see if he is able to receive sildenafil for erectile dysfunction. | -- |
| Which of the patient’s medical conditions would a nurse alert the health care provider about before sildenafil is prescribed? | Status post myocardial infarction |
| Which patients would a nurse determine cannot safely receive therapy with duloxetine for stress urinary incontinence? | -A patient with alcoholism -A patient with hepatitis B |
| A patient with stress urinary incontinence is prescribed duloxetine 40 mg PO BID. The patient also takes paroxetine (for depression), ibuprofen (for osteoarthritis), | -- |
| lisinopril (for hypertension), atorvastatin (for dyslipidemia), and famotidine (for gastroesophageal reflux disease). | -Ibuprofen due to an increased risk for bleeding -Paroxetine due to an increased risk for serotonin syndrome |
| Which patient teaching points would a nurse to share with a female patient prescribed pseudoephedrine for stress urinary incontinence? | -Advise the patient to check her blood pressure at home. -The drug should be taken as prescribed, not taking more or less than what was prescribed. |
| -- | -The patient should avoid taking the drug late in the day or early evening because it may cause jitteriness, anxiety, or restlessness. |
| Which counseling point would a nurse share with a patient who has been newly prescribed oxybutynin 10% gel 1 sachet once daily? | Smoking should not occur when applying topical oxybutynin. |
| Which patient parameter would a nurse closely monitor in a patient who is taking mirabegron? | Blood pressure |
| Which patient education point would a nurse share with a patient who has been newly prescribed tamsulosin for benign prostatic hyperplasia? | Do not crush, chew, or cut open the capsules. |
Created by:
Lightnning54
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