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Pharm Chapter 30
Drug Therapy for Heart Failure
Question | Answer |
---|---|
Condition that results in low cardiac output due to the heart's inability to pump sufficient blood to meet the metabolic demands of the body. | Heart failure |
The result of abnormal electrical impulse conduction in the heart. | Cardiac dysrhythmias |
Active amines, such as epinephrine, norepinephrine, and dopamine that have a "flight or fight" effect on the cardiovascular system. | Catecholamines |
The increased sympathetic nervous system activity is ___________; increasing the patient's heart rate and constricting blood vessels. | Chronotropic |
Enzyme produced in the kidneys in response to impaired blood flow and tissue perfussion. | Renin |
A potent vasoconstrictor and may exert additional direct toxic effects on the heart. | Endothelin |
Two of the natriuretic peptides, atrial or A type NP (ANP) and ___________ are most commonly associated with heart failure. | BNP |
Results in a decrease in cardiac output related to an increase in left atrial and left ventricular end-diastolic pressures and congestion in the pulmonary circulation. | Left sided heart failure |
Results from an accumulation of blood in the systemic venous system. | Right sided heart failure |
Cardiac glycosides prototype | Digoxin |
Digoxin improves symptoms and quality of life; it is considered a _________ line therapy. | Second |
In a patient with an atrial fibrillation with heart failure, digoxin slows the rate of _____________________ (negative chronotropy). | Ventricular contraction |
The margin between effectiveness and toxicity in the blood level of the medication. | Therapeutic index |
Administration of a loading dose of digoxin to reach the therapeutic index. | Digitalization |
Phosphodiesterase inhibitor prototype | Milrinone |
Indicated intermediate and long term as bridge therapy in heart failure. | Milrinone |
While receiving Milrinone, it is important to frequently monitor blood pressure, pulse, and ______________________ | Heart rhythm |
Angiotensin Receptor - Neprilysin Inhibitors prototype | Sacubitril/valsartan |
African Americans are at a higher risk of developing this with administration of sacubitril/valsartan. | Angioedema |
Sinoatrial node modulators prototype | Ivabradine |
One adverse effect of ivabradine is the intermittent enhanced brightness in a limited area of the visual field, halos, or multiple images, which is also called __________. | Phosphene |
Angiotensin-Converting Enzyme Inhibitor prototype for heart failure. | Enalapril |
Beta Adrenergic Blocking Agent prototype for heart failure | Metoprolol |
BBW: beta adrenergic blocking agents - rapid withdrawal of oral forms may result in exacerbation of ________________. | Angina |
Loop diuretic administered to patients with moderate to severe heart failure to reduce edema. | Furosemide |