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Pharm Chapter 30

Drug Therapy for Heart Failure

QuestionAnswer
Condition that results in low cardiac output due to the heart's inability to pump sufficient blood to meet the metabolic demands of the body. Heart failure
The result of abnormal electrical impulse conduction in the heart. Cardiac dysrhythmias
Active amines, such as epinephrine, norepinephrine, and dopamine that have a "flight or fight" effect on the cardiovascular system. Catecholamines
The increased sympathetic nervous system activity is ___________; increasing the patient's heart rate and constricting blood vessels. Chronotropic
Enzyme produced in the kidneys in response to impaired blood flow and tissue perfussion. Renin
A potent vasoconstrictor and may exert additional direct toxic effects on the heart. Endothelin
Two of the natriuretic peptides, atrial or A type NP (ANP) and ___________ are most commonly associated with heart failure. BNP
Results in a decrease in cardiac output related to an increase in left atrial and left ventricular end-diastolic pressures and congestion in the pulmonary circulation. Left sided heart failure
Results from an accumulation of blood in the systemic venous system. Right sided heart failure
Cardiac glycosides prototype Digoxin
Digoxin improves symptoms and quality of life; it is considered a _________ line therapy. Second
In a patient with an atrial fibrillation with heart failure, digoxin slows the rate of _____________________ (negative chronotropy). Ventricular contraction
The margin between effectiveness and toxicity in the blood level of the medication. Therapeutic index
Administration of a loading dose of digoxin to reach the therapeutic index. Digitalization
Phosphodiesterase inhibitor prototype Milrinone
Indicated intermediate and long term as bridge therapy in heart failure. Milrinone
While receiving Milrinone, it is important to frequently monitor blood pressure, pulse, and ______________________ Heart rhythm
Angiotensin Receptor - Neprilysin Inhibitors prototype Sacubitril/valsartan
African Americans are at a higher risk of developing this with administration of sacubitril/valsartan. Angioedema
Sinoatrial node modulators prototype Ivabradine
One adverse effect of ivabradine is the intermittent enhanced brightness in a limited area of the visual field, halos, or multiple images, which is also called __________. Phosphene
Angiotensin-Converting Enzyme Inhibitor prototype for heart failure. Enalapril
Beta Adrenergic Blocking Agent prototype for heart failure Metoprolol
BBW: beta adrenergic blocking agents - rapid withdrawal of oral forms may result in exacerbation of ________________. Angina
Loop diuretic administered to patients with moderate to severe heart failure to reduce edema. Furosemide
Created by: mcnabb
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