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Anticoag
Drug | Class | A/E (Besides Bleeding) | Considerations |
---|---|---|---|
Heparin | enhances antithrombin | Heparin induced thrombocytopenia (HIT) | Ok for preggy aPTT (60-80) |
Daletparin | LMW Hep | ||
Fondaparinux | LMW Hep | ||
Warfarin | Inhibits Vit K factors(VII, IX, X) Inhibits prothrombin cascade | Fetal hemmorhage/teratogenesis | Antidote:Vitamin K no aspirin/acetaminophen no preggy |
Dabigatran etexilate | Direct thrombin inhibitor | GI | Watch kidneys -Doesnt require much monitoring and carries low risk of A/E |
Rivaroxaban | Direct factor Xa inhib inactivation of fibrinogen to fibrin | spinal/epidural hematoma with paralysis is possible | not preggy safe can impair excretion |
Clopidogrel | Antiplatelet aggregation | similar to aspirin (GI bleeds, etc) | |
Plasugrel | sim to clopidogrel | ||
Ticagrelor | sim to clopidogrel | ||
Eptifibatide | Antiplatelet | Super high risk for bleeding | monitor bleeding |
Tirofiban | Antiplatelet | SUper high risk for bleeding | monitor bleeding |