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Interaction/Effect

InteractionEffect
Statins Grapefruit juice
Antiplatlets , NSAID , Anticoagulant drugs, SSRI antidepressants Increase Risk of bleeding
Multivalent ions + Levothyroxine Fluoroquinolones Bisphosphonates Tetracyclines (Reduce the effectiveness of a drug )
Nitrates + PDE5 inhibitors Causes hypotension - risk of severe hypotension if both drugs are taken together
ACE inhibitors Risk of hyperkalemia Potassium - elevating drugs , k - elevating drugs should be avoided
Ritonavir + Protease inhibitors Less dose can be used to achieve the same clinical effect w/o causing excess side effects
Beta - Blockers + Calcium channel blockers Risk of heart failure and slow heart rate
Broad - spectrum antibiotics + warfarin Produces vit K - means risk of bleeding
Digoxin + Loop or thiazide diuretics Low potassium levels
Aminoglycosides + Loop diuretics Causes ototoxicity and kidney damage
Antihistamines + Benzodiazepines, SSRIs, Antipsychotic drugs Increases the risk of sedation
Macrolides, Amiodarone, SSRIs, Fluoroquinolones Quinine, Antipsychotic drugs , Quinine Prolong the QT interval means that they increase the risk of heart rhythm problems, arrhythmias the risk of QT prolongation. All drugs listed carry all these Risk
Corticosteroids + NSAIDs Risk of peptic ulceration and GI bleeding
MAO inhibitors + { Tyramine } Increase the risk of hypertensive crisis when taken with MAO inhibitors
{Omeprazole} + Clopidogrel Reduces the antiplatelet effect
{Macrolides} + Statins Inhibits CYP enzymes / adverse effect increases
Sulfonylureas, Metformin, Thiazolidinediones Each drug individually cause hypoglycemia. Increases the risk of hypoglycemia (any other drug class that lowers blood glucose levels)
{Phenytoin) + Warfarin, Estrogens, Progestogens induces CYP enzymes - reduces plasma concentrations of drugs - reducing their clinical effects
(Corticosteroids)+ Beta - 2 agonists increases the risk of hypokalemia (low blood potassium levels)
Alpha-blockers + Antihypertensive drugs can lower blood pressure. taking it with other drugs that lower blood pressure can cause an ADDITIVE effect - (dangerously low blood pressure)-- (two or more drugs classes) that reduce BP
Created by: laylaoxendine
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